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Table 2 Laboratory tests results collected before the diagnosis in ALL and JIA patients

From: Persistent osteoarticular pain in children: early clinical and laboratory findings suggestive of acute lymphoblastic leukemia (a multicenter case-control study of 147 patients)

 

ALL

JIA

p*

Blood count

(median [interquartile range])

(median [interquartile range])

 

 WBC count, 109/L

5.1 [4.2–6.5]

8.4 [7.0–10.3]

< 0.001

  Neutrophils, 109/L

1.6 [0.8–2.9]

4.6 [3.3–5.4]

< 0.001

  Eosinophils, 109/L

0.02 [0–0.06]

0.2 [0.1–0.3]

< 0.001

  Basophils, 109/L

0.003 [0–0.03]

0.03 [0.02–0.05]

< 0.001

  Lymphocytes, 109/L

2.6 [1.8–4.2]

2.9 [2.3–3.6]

0.56

  Monocytes, 109/L

0.2 [0.1–0.4]

0.6 [0.5–0.8]

< 0.001

 Hgb, g/dL

10.6 [9.2–12.1]

11.9 [11,3-12,9]

0,001

 HCT, %

31.8 [27.0–35.5]

35.9 [33.3–38.6]

< 0.001

 MCV, fL

83 [78–86]

80 [76–83]

0.009

 MCHC, g/dL

34 [33–34]

34 [33–34]

0.84

 Platelets, 109/L

218 [158–310]

377 [298–439]

< 0.001

Inflammatory parameters

 1st hr. ESR, mm

56 [35–98]

25 [12–48]

< 0.001

 CRP, mg/L

46 [9–80]

8 [2–26]

< 0.001

  1. * Univariate analysis with Wilcoxon test
  2. ALL Acute lymphoblastic leukemia, CRP C-reactive protein, ESR Erythrocyte sedimentation rate, HCT Hematocrit, Hgb Hemoglobin, JIA Juvenile idiopathic arthritis, MCHC Mean corpuscular hemoglobin concentration, MCV Mean corpuscular volume, WBC White blood cells