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Table 2 Cytokine concentration in patient serum and cerebrospinal fluid

From: Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants

Cytokine

SERUM (pg/mL)

CSF (pg/mL)

Patient

Controls (mean ± SD)

Patient

Controls (mean ± SD)

bFGF

2.28

42.39 ± 32.66

0.37

0.12 ± 0.04

CRP (S: × 106; CSF: × 103)

1.62

1.42 ± 1.52

28.42

106.67 ± 173.26

Eotaxin

50.88

59.43 ± 29.41

19.99

3.42 ± 3.47

Eotaxin-3

0.95

20.77 ± 17.00

ND

ND

GM-CSF

2.00

0.44 ± 0.37

0.23

0.33 ± 012

ICAM-1 (S: ×103; CSF: × 103)

749.69

568.43 ± 82.32

29.03

11.95 ± 4.21

IFN-γ (S: × 103)

2.58

0.003 ± 0.001

12.39

0.64 ± 0.37

IL-1β

ND

ND

ND

ND

IL-1α

0.02

0.08 ± 0.09

0.43

0.44 ± 0.56

IL-2

ND

0.35 ± 0.17

0.02

0.01 ± NDa

IL-4

0.06

0.03 ± 0.02

ND

0.03 ± NDa

IL-5

ND

2.58 ± NDa

0.62

0.33 ± 0.04

IL-6

1.96

0.29 ± 0.35

1.67

0.46 ± 0.14

IL-7

21.56

15.43 ± 7.24

2.21

2.64 ± 0.85

IL-8

9.76

5.35 ± 2.94

43.93

12.75 ± 10.52

IL-10

1.29

0.33 ± 0.03

0.04

ND

IL-12/IL-23p40

616.99

285.75 ± 70.30

11.21

3.26 ± 0.82

IL-12p70

0.13

0.04 ± NDa

ND

0.09 ± 0.05

IL-13

0.80

0.32 ± 0.12

ND

0.55 ± NDa

IL-15

3.17

1.78 ± 0.46

5.11

1.94 ± 0.45

IL-16

239.07

203.49 ± 73.13

6.67

2.92 ± 1.55

IL-17A

6.83

3.30 ± 2.74

ND

0.32 ± 0.44

IP-10 (S: ×103; CSF: ×103)

169.40

0.45 ± 0.16

2.80

0.03 ± 0.02

MCP-1

338.23

195.79 ± 9.00

557.74

368.26 ± 80.38

MCP-4

21.40

70.85 ± 7.68

6.40

3.73 ± 2.13

MDC (S: ×103)

1.07

1.93 ± 0.09

76.25

2.49 ± 0.25

MIP-1α

28.33

9.10 ± 2.19

18.95

3.07 ± 1.67

MIP-1β

179.78

85.20 ± 74.99

11.32

6.48 ± 4.48

PIGF

48.42

24.00 ± 7.56

15.29

17.79 ± 0.51

SAA (S: ×106; CSF: ×103)

16.24

22.28 ± 31.34

31.27

214.20 ± 368.14

sFIt-1

84.64

90.11 ± 1.99

35.51

12.93 ± 7.90

TARC

147.94

370.04 ± 179.10

3.37

0.38 ± 0.10

Tie-2 (S: ×103)

5.75

4.19 ± 0.99

17.39

9.71 ± 2.72

TNF-α

7.98

3.50 ± 0.96

0.22

0.04 ± 0.00

TNF-β

2.43

0.56 ± 0.51

ND

0.06 ± 0.00

VCAM-1 (S: ×106; CSF: ×103)

1.31

0.70 ± 0.05

67.62

19.20 ± 6.70

VEGF

362.13

289.56 ± 33.77

3.22

4.38 ± 1.50

VEGF

770.44

573.56 ± 40.83

1.77

3.12 ± 0.69

VEGF-C

226.30

358.58 ± 95.79

ND

8.52 ± NDa

VEGF-D

304.25

350.99 ± 119.84

21.61

3.04 ± 2.40

  1. Cytokine concentrations in serum (S) and cerebrospinal fluid (CSF) from the patient and children (n = 3 for serum, n = 3 for CSF) admitted to BC Children’s Hospital for non-inflammatory conditions. Patient values that were 2 SD below or above control mean values are shown in bold
  2. ND no data; values below the lower range of detection: pg/ml, Eotaxin 3; 3.26, IL-1β; 0.04, IL-2; 0.09, IL-4; 0.02, IL-5; 0.22, IL-10; 0.03, IL-12p70; 0.11, IL-13; 0.24, IL-17A; 0.74, TNF-β; 0.05, VEGF-C; 11.1
  3. aSD was not calculated because values were below the level of detection for at least one individual