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Table 2 Cytokine concentration in patient serum and cerebrospinal fluid

From: Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants

Cytokine SERUM (pg/mL) CSF (pg/mL)
Patient Controls (mean ± SD) Patient Controls (mean ± SD)
bFGF 2.28 42.39 ± 32.66 0.37 0.12 ± 0.04
CRP (S: × 106; CSF: × 103) 1.62 1.42 ± 1.52 28.42 106.67 ± 173.26
Eotaxin 50.88 59.43 ± 29.41 19.99 3.42 ± 3.47
Eotaxin-3 0.95 20.77 ± 17.00 ND ND
GM-CSF 2.00 0.44 ± 0.37 0.23 0.33 ± 012
ICAM-1 (S: ×103; CSF: × 103) 749.69 568.43 ± 82.32 29.03 11.95 ± 4.21
IFN-γ (S: × 103) 2.58 0.003 ± 0.001 12.39 0.64 ± 0.37
IL-1β ND ND ND ND
IL-1α 0.02 0.08 ± 0.09 0.43 0.44 ± 0.56
IL-2 ND 0.35 ± 0.17 0.02 0.01 ± NDa
IL-4 0.06 0.03 ± 0.02 ND 0.03 ± NDa
IL-5 ND 2.58 ± NDa 0.62 0.33 ± 0.04
IL-6 1.96 0.29 ± 0.35 1.67 0.46 ± 0.14
IL-7 21.56 15.43 ± 7.24 2.21 2.64 ± 0.85
IL-8 9.76 5.35 ± 2.94 43.93 12.75 ± 10.52
IL-10 1.29 0.33 ± 0.03 0.04 ND
IL-12/IL-23p40 616.99 285.75 ± 70.30 11.21 3.26 ± 0.82
IL-12p70 0.13 0.04 ± NDa ND 0.09 ± 0.05
IL-13 0.80 0.32 ± 0.12 ND 0.55 ± NDa
IL-15 3.17 1.78 ± 0.46 5.11 1.94 ± 0.45
IL-16 239.07 203.49 ± 73.13 6.67 2.92 ± 1.55
IL-17A 6.83 3.30 ± 2.74 ND 0.32 ± 0.44
IP-10 (S: ×103; CSF: ×103) 169.40 0.45 ± 0.16 2.80 0.03 ± 0.02
MCP-1 338.23 195.79 ± 9.00 557.74 368.26 ± 80.38
MCP-4 21.40 70.85 ± 7.68 6.40 3.73 ± 2.13
MDC (S: ×103) 1.07 1.93 ± 0.09 76.25 2.49 ± 0.25
MIP-1α 28.33 9.10 ± 2.19 18.95 3.07 ± 1.67
MIP-1β 179.78 85.20 ± 74.99 11.32 6.48 ± 4.48
PIGF 48.42 24.00 ± 7.56 15.29 17.79 ± 0.51
SAA (S: ×106; CSF: ×103) 16.24 22.28 ± 31.34 31.27 214.20 ± 368.14
sFIt-1 84.64 90.11 ± 1.99 35.51 12.93 ± 7.90
TARC 147.94 370.04 ± 179.10 3.37 0.38 ± 0.10
Tie-2 (S: ×103) 5.75 4.19 ± 0.99 17.39 9.71 ± 2.72
TNF-α 7.98 3.50 ± 0.96 0.22 0.04 ± 0.00
TNF-β 2.43 0.56 ± 0.51 ND 0.06 ± 0.00
VCAM-1 (S: ×106; CSF: ×103) 1.31 0.70 ± 0.05 67.62 19.20 ± 6.70
VEGF 362.13 289.56 ± 33.77 3.22 4.38 ± 1.50
VEGF 770.44 573.56 ± 40.83 1.77 3.12 ± 0.69
VEGF-C 226.30 358.58 ± 95.79 ND 8.52 ± NDa
VEGF-D 304.25 350.99 ± 119.84 21.61 3.04 ± 2.40
  1. Cytokine concentrations in serum (S) and cerebrospinal fluid (CSF) from the patient and children (n = 3 for serum, n = 3 for CSF) admitted to BC Children’s Hospital for non-inflammatory conditions. Patient values that were 2 SD below or above control mean values are shown in bold
  2. ND no data; values below the lower range of detection: pg/ml, Eotaxin 3; 3.26, IL-1β; 0.04, IL-2; 0.09, IL-4; 0.02, IL-5; 0.22, IL-10; 0.03, IL-12p70; 0.11, IL-13; 0.24, IL-17A; 0.74, TNF-β; 0.05, VEGF-C; 11.1
  3. aSD was not calculated because values were below the level of detection for at least one individual