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Table 1 Frequently abnormal clinical laboratory values over the course of diseasea

From: Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants

  Patient median Patient range Normal range
A. Complete Blood Cell count (CBC) and liver function values
 Hb (g/L) 114 96–126 125–165
 WBC (× 109/L) 3 1.7–10.9 3.9–10.2
 Platelets (× 109/L) 172 151–231 180–440
 ALT (U/L) 83 25–650 0–50
 AST (U/L) 97.5 66–178 0–36
 LDH (U/L) 1151 133–1754 120–300
B. Inflammatory markers
 CRP (mg/L) 5 0–45 0–5
 ESR (mm) 14 4–42 0–15
 Ferritin (ug/L) 70 29–465 31–177
 SAA (ng/mL) 11,765 1752 – 193,855 1000–5000
  1. aMedian and range calculated from test results obtained approximately three times a year over 10 years (age 5–14 yrs). Normal ranges are age-specific values from the BC Children’s Hospital Clinical Laboratory. Changes in parameters did not correlate with alterations in clinical state and neither correlated with treatment modalities, except for a decrease in SAA upon treatment with canakinumab (Fig. 1)