Complexity in unclassified auto-inflammatory disease: a case report illustrating the potential for disease arising from the allelic burden of multiple variants

Table 1 Frequently abnormal clinical laboratory values over the course of disease^a

	Patient median	Patient range	Normal range
A. Complete Blood Cell count (CBC) and liver function values
Hb (g/L)	114	96–126	125–165
WBC (× 10⁹/L)	3	1.7–10.9	3.9–10.2
Platelets (× 10⁹/L)	172	151–231	180–440
ALT (U/L)	83	25–650	0–50
AST (U/L)	97.5	66–178	0–36
LDH (U/L)	1151	133–1754	120–300
B. Inflammatory markers
CRP (mg/L)	5	0–45	0–5
ESR (mm)	14	4–42	0–15
Ferritin (ug/L)	70	29–465	31–177
SAA (ng/mL)	11,765	1752 – 193,855	1000–5000

^aMedian and range calculated from test results obtained approximately three times a year over 10 years (age 5–14 yrs). Normal ranges are age-specific values from the BC Children’s Hospital Clinical Laboratory. Changes in parameters did not correlate with alterations in clinical state and neither correlated with treatment modalities, except for a decrease in SAA upon treatment with canakinumab (Fig. 1)

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