Table 1 (abstract A38). Characteristics of biologic switchers in the CARRA Registry
| Â | All 1st Biologic Switchers (N = 349) | Switch for Inefficacy/Disease Flare n= 202 | Switch for all other reasons n=147 | p value |
|---|---|---|---|---|
Reason for switch: n, % | Â | Â | Â | xx |
Adverse event | 11 (3) | 0 | 11 (7) | Â |
Ineffective/Disease Flare | 202 (58) | 202 (100) | 0 | Â |
Infusion/Injection reaction | 7 (2) | 0 | 7 (5) | Â |
Mild AE/Intolerance of Delivery mode | 32 (9) | 0 | 32 (22) | Â |
other | 66 (19) | 0 | 66 (45) | Â |
Unknown/Incomplete data | 31 (9) | 0 | 31 (21) | Â |
Age (years) median, IQR | 10 (7-13) | 11 (8-13) | 9 (6-13) | 0.0099 |
Female (N, %) | 274 (79) | 157 (78) | 117 (80) | ns |
Time from start medication to switch (start 2nd) (days) median, IQR | 394 (192-891) | 306 (175-633) | 660 (252-1233) | <0.0001 |
Elapsed time from discontinuation of 1st biologic to start of 2nd biologic (days) median, IQR | 0 (0-21) | 0 (0-7) | 1 (0-80) | <0.0001 |
Calendar year of switch: median, range, IQR | 2016 (2015-2017) | 2016 (2015-2017) | 2016 (2014-2017) | ns |
Type of switch: n,% | Â | Â | Â | 0.03 |
Etanercept to other TNF | 221 (63) | 130 (64) | 91 (62) | Â |
Etanercept to non TNF | 33 (10) | 19 (9) | 14 (10) | Â |
Other TNF to Etanercept | 28 (8) | 10 (5) | 18 (12) | Â |
Other TNF to non TNF | 21 (6) | 16 (8) | 5 (3) | Â |
Non TNF to Etanercept | 7 (2) | 1 (1) | 6 (4) | Â |
Non TNF to other TNF | 4 (1) | 3 (1.5) | 1 (1) | Â |
Non TNF to non TNF | 5 (1) | 3 (1.5) | 2 (1) | Â |
Other TNF to other TNF | 30 (9) | 20 (10) | 10 (7) | Â |