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Table 3 Different cutoff values of N-terminal pro-brain natriuretic peptide in predicting IVIG resistance in KD stratified by age

From: The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study

Age group Cutoff value of NT-ProBNP Category Response to IVIG Sen Spe PPV NPV Diagnostic accuracy OR (95%CI) AUC P
Resistance Response
< 1 year NT-ProBNP≥2480 pg/ml High risk 6 20 75.0% 71.8% 23.1% 96.2% 72.3% 7.65 (1.42–41.12) 0.77 0.014*
Low risk 2 51
1–2 years NT-ProBNP≥2800 pg/ml High risk 7 21 50.0% 77.9% 25.0% 91.4% 74.3% 3.52 (1.11–11.18) 0.61 0.045*
Low risk 7 74
2–6 years NT-ProBNP≥3710 pg/ml High risk 12 21 52.2% 86.3% 36.4% 92.3% 81.8% 6.86 (2.68–17.53) 0.69 < 0.001*
Low risk 11 132
Total age NT-ProBNP≥3755 pg/ml High risk 24 54 44.4% 84.1% 30.8% 90.5% 78.6% 4.22 (2.29–7.78) 0.64 < 0.001*
Low risk 30 285
  1. Sen, sensitivity; Spe, specificity; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve;
  2. NT-ProBNP, N-terminal probrain natriuretic peptide; IVIG, intravenous immunoglobulin;
  3. *Statistically significant (P < 0.05)