The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study

Table 3 Different cutoff values of N-terminal pro-brain natriuretic peptide in predicting IVIG resistance in KD stratified by age

Age group	Cutoff value of NT-ProBNP	Category	Response to IVIG		Sen	Spe	PPV	NPV	Diagnostic accuracy	OR (95%CI)	AUC	P
Age group	Cutoff value of NT-ProBNP	Category	Resistance	Response	Sen	Spe	PPV	NPV	Diagnostic accuracy	OR (95%CI)	AUC	P
< 1 year	NT-ProBNP≥2480 pg/ml	High risk	6	20	75.0%	71.8%	23.1%	96.2%	72.3%	7.65 (1.42–41.12)	0.77	0.014*
< 1 year	NT-ProBNP≥2480 pg/ml	Low risk	2	51	75.0%	71.8%	23.1%	96.2%	72.3%	7.65 (1.42–41.12)	0.77	0.014*
1–2 years	NT-ProBNP≥2800 pg/ml	High risk	7	21	50.0%	77.9%	25.0%	91.4%	74.3%	3.52 (1.11–11.18)	0.61	0.045*
1–2 years	NT-ProBNP≥2800 pg/ml	Low risk	7	74	50.0%	77.9%	25.0%	91.4%	74.3%	3.52 (1.11–11.18)	0.61	0.045*
2–6 years	NT-ProBNP≥3710 pg/ml	High risk	12	21	52.2%	86.3%	36.4%	92.3%	81.8%	6.86 (2.68–17.53)	0.69	< 0.001*
2–6 years	NT-ProBNP≥3710 pg/ml	Low risk	11	132	52.2%	86.3%	36.4%	92.3%	81.8%	6.86 (2.68–17.53)	0.69	< 0.001*
Total age	NT-ProBNP≥3755 pg/ml	High risk	24	54	44.4%	84.1%	30.8%	90.5%	78.6%	4.22 (2.29–7.78)	0.64	< 0.001*
Total age	NT-ProBNP≥3755 pg/ml	Low risk	30	285	44.4%	84.1%	30.8%	90.5%	78.6%	4.22 (2.29–7.78)	0.64	< 0.001*

Sen, sensitivity; Spe, specificity; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve;
NT-ProBNP, N-terminal probrain natriuretic peptide; IVIG, intravenous immunoglobulin;
*Statistically significant (P < 0.05)

ISSN: 1546-0096