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Table 1 Comparison of the demographic characteristics, clinical and laboratory data between the IVIG-response and IVIG-resistance patients with KD in total age before initial IVIG treatment

From: The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study

  IVIG-resistance (n = 54) IVIG-response (n = 339) P value
Age (months) 28.50 [14.00–57.00] 24.00 [13.00–42.00] 0.051
Male (%) 28(51.9) 199(58.7) 0.344
Clinical manifestations
 Rash, n (%) 46(85.2) 263(77.6) 0.206
 Bilateral bulbar conjunctive injection, n (%) 48(88.9) 312(92.0) 0.430
 Edema & erythema of the extremities, n (%) 33(61.1) 208(61.4) 0.973
 Erythema of oral and pharyngeal mucosa, n (%) 53(98.1) 317(93.5) 0.343
 Cervical lymphadenopathy, n (%) 29(53.7) 152(44.8) 0.225
 Incomplete KD, n (%) 15(27.8) 117(34.5) 0.330
 Pericardial effusion (%) 6(11.1) 8(2.4) 0.006*
 Valve regurgitation (%) 9(16.7) 37(1.9) 0.222
 Cardiac enlargement (%) 7(13.0) 30(8.8) 0.336
 Ventricular systolic dysfunction (%) 1(1.9) 1(0.3) 0.256
 Coronary artery lesions (CALs), n (%) 10(18.5) 35(10.3) 0.079
Blood test from fever onset, days 5.00 [4.00–5.00] 5.00 [4.00–5.00] 0.076
Fever duration before IVIG administration, days 5.00 [5.00–6.00] 5.00 [5.00–6.00] 0.116
Laboratory features
 WBC count (109/L) 14.15 [10.83–16.50] 13.40 [10.60–16.70] 0.863
 Neutrophils (%) 71.30 [61.15–83.93] 66.20 [56.00–76.20] 0.003*
 Hemoglobin (g/L) 106.50 [97.75–115.00] 108.00 [101.00–115.00] 0.553
 PLT count (109/L) 294.50 [239.25–343.75] 330.00 [276.00–404.00] <.001*
 CRP (mg/L) 85.00 [61.75–137.50] 69.00 [41.00–103.00] 0.022*
 ESR (mm/h) 66.00 [45.50–94.00] 64.00 [47.00–81.00] 0.443
 AST (IU/L) 30.50 [23.00–57.50] 30.00 [24.00–47.00] 0.896
 ALT (IU/L) 44.00 [25.75–96.50] 36.00 [20.00–74.00] 0.809
 ALB (g/L) 36.05 [32.00–38.90] 37.60 [35.20–41.10] 0.002*
 Total bilirubin (mg/L) 6.80 [4.75–12.90] 6.10 [3.70–8.70] 0.018*
 Urea nitrogen (mmol/L) 2.90 [2.40–3.50] 2.70 [2.10–3.20] 0.063
 Creatinine (umol/L) 29.00 [24.00–36.00] 27.00 [22.00–31.00] 0.123
 Sodium (mmol/L) 135.00 [132.75–137.00] 137.00 [135.00–139.00] < 0.001*
 Potassium (mmol/L) 4.04 [3.50–4.41] 4.12 [3.77–4.56] 0.026*
Troponin (ug/L) 0.12 [0.12–0.13] 0.12 [0.12–0.12] 0.139
  1. The data are presented as the median with the 25th and 75th percentiles in square brackets for continuous variables and as the percentage for the categorical variables
  2. IVIG, intravenous immunoglobulin; CALs, Coronary artery lesions; WBC, white blood cell; PLT, platelet; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, Albumin; NT-ProBNP, N-terminal probrain natriuretic peptide; *Statistically significant (P < 0.05)