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Table 1 Comparison of the demographic characteristics, clinical and laboratory data between the IVIG-response and IVIG-resistance patients with KD in total age before initial IVIG treatment

From: The role of age-specific N-terminal pro-brain natriuretic peptide cutoff values in predicting intravenous immunoglobulin resistance in Kawasaki disease: a prospective cohort study

 

IVIG-resistance (n = 54)

IVIG-response (n = 339)

P value

Age (months)

28.50 [14.00–57.00]

24.00 [13.00–42.00]

0.051

Male (%)

28(51.9)

199(58.7)

0.344

Clinical manifestations

 Rash, n (%)

46(85.2)

263(77.6)

0.206

 Bilateral bulbar conjunctive injection, n (%)

48(88.9)

312(92.0)

0.430

 Edema & erythema of the extremities, n (%)

33(61.1)

208(61.4)

0.973

 Erythema of oral and pharyngeal mucosa, n (%)

53(98.1)

317(93.5)

0.343

 Cervical lymphadenopathy, n (%)

29(53.7)

152(44.8)

0.225

 Incomplete KD, n (%)

15(27.8)

117(34.5)

0.330

 Pericardial effusion (%)

6(11.1)

8(2.4)

0.006*

 Valve regurgitation (%)

9(16.7)

37(1.9)

0.222

 Cardiac enlargement (%)

7(13.0)

30(8.8)

0.336

 Ventricular systolic dysfunction (%)

1(1.9)

1(0.3)

0.256

 Coronary artery lesions (CALs), n (%)

10(18.5)

35(10.3)

0.079

Blood test from fever onset, days

5.00 [4.00–5.00]

5.00 [4.00–5.00]

0.076

Fever duration before IVIG administration, days

5.00 [5.00–6.00]

5.00 [5.00–6.00]

0.116

Laboratory features

 WBC count (109/L)

14.15 [10.83–16.50]

13.40 [10.60–16.70]

0.863

 Neutrophils (%)

71.30 [61.15–83.93]

66.20 [56.00–76.20]

0.003*

 Hemoglobin (g/L)

106.50 [97.75–115.00]

108.00 [101.00–115.00]

0.553

 PLT count (109/L)

294.50 [239.25–343.75]

330.00 [276.00–404.00]

<.001*

 CRP (mg/L)

85.00 [61.75–137.50]

69.00 [41.00–103.00]

0.022*

 ESR (mm/h)

66.00 [45.50–94.00]

64.00 [47.00–81.00]

0.443

 AST (IU/L)

30.50 [23.00–57.50]

30.00 [24.00–47.00]

0.896

 ALT (IU/L)

44.00 [25.75–96.50]

36.00 [20.00–74.00]

0.809

 ALB (g/L)

36.05 [32.00–38.90]

37.60 [35.20–41.10]

0.002*

 Total bilirubin (mg/L)

6.80 [4.75–12.90]

6.10 [3.70–8.70]

0.018*

 Urea nitrogen (mmol/L)

2.90 [2.40–3.50]

2.70 [2.10–3.20]

0.063

 Creatinine (umol/L)

29.00 [24.00–36.00]

27.00 [22.00–31.00]

0.123

 Sodium (mmol/L)

135.00 [132.75–137.00]

137.00 [135.00–139.00]

< 0.001*

 Potassium (mmol/L)

4.04 [3.50–4.41]

4.12 [3.77–4.56]

0.026*

Troponin (ug/L)

0.12 [0.12–0.13]

0.12 [0.12–0.12]

0.139

  1. The data are presented as the median with the 25th and 75th percentiles in square brackets for continuous variables and as the percentage for the categorical variables
  2. IVIG, intravenous immunoglobulin; CALs, Coronary artery lesions; WBC, white blood cell; PLT, platelet; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALB, Albumin; NT-ProBNP, N-terminal probrain natriuretic peptide; *Statistically significant (P < 0.05)