Skip to main content

Table 2 Lectin protein concentrations according to JIA subtype early in disease course and at 17-year follow-up

From: Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: a longitudinal study of the Nordic JIA cohort

 

n

MBL

H-ficolin

M-ficolin

CL-K1

MASP-1

MASP-3

Baseline

 Total cohort

238

3.1(1.2–4.7)

26.3(21.5–29.9)

3.0(2.4–3.9)

0.28(0.23–0.34)

9.9(7.4–13.2)

8.1(6.7–9.3)

 sJIA

11

3.8(0.8–4.7)

27.2(20.4–29.6)

4.1(3.4–6.3)

0.31(0.21–0.37)

7.4(4.8–12.1)

8.5(5.7–10.7)

 Oligo persist

113

3.3(1.9–4.5)

25.8(21.8–29.9)

3.0(2.4–3.8)

0.28(0.23–0.34)

10.3(7.9–13.3)

8.1(7.2–9.6)

 Oligo ext

8

3.1(1.2–4.4)

26.2(21.6–32.3)

3.5(2.3–4.8)

0.30(0.24–0.42)

7.0(5.7–11.5)

8.1(6.2–8.5)

 Poly RF-

47

4.4(2.4–6.3)

26.7(21.2–35.3)

3.1(2.4–4.3)

0.28(0.23–0.33)

9.0(6.9–11.7)

7.7(6.4–9.0)

 Poly RF+

5

2.3(2.3–4.6)

24.0(18.4–26.3)

2.8(2.4–2.8)

0.25(0.24–0.35)

8.8(8.5–10.7)

10.0(7.8–10.4)

 Psoriatic

2

2.5(2.3–2.8)

24.5(20.4–28.6)

3.3(2.7–3.8)

0.23(0.19–0.26)

15.0(14.9–15.0)

8.2(5.6–10.9)

 ERA

20

1.9(0.5–2.8)

26.4(21.9–29.4)

2.9(2.1–3.5)

0.26(0.20–0.33)

10.2(7.0–14.4)

8.1(6.5–9.0)

 Undiff

32

2.2(0.5–4.7)

27.0(21.2–29.5)

3.0(2.6–3.5)

0.29(0.26–0.35)

10.6(8.5–3.6)

8.1(7.1–9.0)

17-year follow-up

 Total cohort

293

2.0(0.7–3.5)

22.5(18.9–26.1)

2.1(1.7–3.0)

0.24(0.21–0.28)

8.8(6.5–11.3)

6.7(5.6–8.4)

 sJIA

13

3.3(1.6–3.8)

21.8(18.0–24.6)

2.2(1.6–2.4)

0.23(0.21–0.25)

8.2(7.7–10.5)

6.4(5.9–6.9)

 Oligo persist

66

2.2(0.8–3.3)

22.1(18.8–25.6)

2.3(1.7–3.0)

0.24(0.21–0.27)

9.0(6.8–11.5)

6.6(5.1–8.6)

 Oligo ext

55

2.0(0.6–3.3)

21.1(18.5–24.0)

2.0(1.7–2.7)

0.24(0.21–0.28)

9.5(7.5–13.0)

6.7(5.7–8.5)

 Poly RF-

53

2.6(1.2–3.8)

22.3(18.8–25.4)

2.1(1.7–2.7)

0.24(0.22–0.28)

9.8(7.5–9.9)

6.7(5.7–8.4)

 Poly RF+

5

1.3(0.0–2.2)

31.4(25.1–36.1)

2.1(1.8–3.3)

0.25(0.23–0.34)

8.4(6.3–10.9)

8.7(7.5–8.8)

 Psoriatic

19

2.0(0.7–4.3)

24.9(21.8–30.3)

2.2(1.8–3.1)

0.27(0.22–0.28)

8.7(5.6–12.1)

6.6(5.7–9.1)

 ERA

33

1.4(0.6–2.0)

25.4(22.1–30.6)

1.9(1.6–2.6)

0.24(0.20–0.27)

8.1(6.3–10.5)

7.2(5.7–8.9)

 Undiff

49

1.9(0.6–3.6)

20.8(17.2–25.8)

2.4(1.9–3.3)

0.24(0.21–0.27)

8.6(6.4–11.7)

6.4(5.3–7.8)

  1. Serum values are medians in μg/mL with 1st-3rd interquartile range (IQR). MBL mannan binding lectin, MASP MBL-associated serine proteases, CL-K1 collectin kidney, sJIA systemic JIA, Oligo persist oligo persistent JIA, Oligo ext. oligo extended JIA, Poly RF- polyarticular rheumatoid factor negative JIA, Poly RF+ polyarticular rheumatoid factor positive JIA, ERA enthesitis-related arthritis, Undiff undifferentiated JIA