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Fig. 4 | Pediatric Rheumatology

Fig. 4

From: The pain trajectory of juvenile idiopathic arthritis (JIA): translating from adolescent patient report to behavioural sensitivity in a juvenile animal model

Fig. 4

Pain behaviour was measured in animals receiving intraarticular injections of CFA or saline twice (at either P8/P21 followed by P40, a). CFA + CFA animals could be separated into animals with high or low pain sensitivity based on weight bearing measurements taken at baseline–prior to the second monoarthritis induction (subgroups indicated by dashed boxes). Animals with high pain sensitivity (n = 9, orange) have a significant reduction in baseline weight bearing compared to Saline+CFA (n = 22, purple) or Saline+Saline animals (n = 24, black) (p < 0.001, b) while those with a low pain sensitivity (n = 12, blue) did not. Following monoarthritis induction animals with high pain sensitivity experienced a prolonged reduction in weight bearing compared to animals with low pain sensitivity and Saline+CFA animals (p < 0.001, c). + p < 0.05 between indicated groups. * p < 0.05 between high sensitivity and low sensitivity/Saline+CFA at indicated time-points

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Pediatric Rheumatology

ISSN: 1546-0096