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Table 1 Baseline characteristics of study patients considered as a whole and by achievement of ID

From: A prediction rule for lack of achievement of inactive disease with methotrexate as the sole disease-modifying antirheumatic therapy in juvenile idiopathic arthritis

Features

All patients (n = 375)

Patients who did not achieve ID (n = 146)

Patients who achieved ID (n = 229)

P#

Gender

   

0.0004

 Female

299 (79.7)

103 (70.5)

195 (85.6)

 

 Male

76 (20.3)

43 (29.5)

33 (14.4)

 

Median (IQR) age at disease onset, yrs

3.2 (1.7–7.0)

4.4 (1.9–8.2)

2.7 (1.7–5.5)

0.002

Median (IQR) age, yrs

5.6 (3.0–9.5)

6.3 (3.3–9.9)

4.9 (2.8–9)

0.05

Median (IQR) disease duration, yrs

0.8 (0.4–2.4)

0.8 (0.3–2.5)

0.9 (0.4–2.4)

0.08

Median (IQR) follow-up time, yrs

1.5 (0.8–2.5)

1.2 (0.5–2.6)

1.7 (1–2.5)

0.002

Functional phenotypes§

   

< 0.0001

 Systemic arthritis

29/373 (7.8)

25 (17.2)

4 (1.8)

 

 Polyarthritis

151/373 (40.5)

59 (40.7)

92 (40.3)

 

 Oligoarthritis

174/373 (46.6)

49 (33.8)

125 (54.8)

 

 Enthesitis-related arthritis

19/373 (5.1)

12 (8.3)

7 (3.1)

 

Patients with positive ANA

264/371 (71.2)

79/133 (59.4)

185/226 (81.9)

< 0.0001

Median (IQR) no. of active joints

5 (3–8)

5 (3–10)

5 (3–7)

0.51

Median (IQR) ESR, mm/h (n = 313)

40 (21–58)

46 (24–62)

35.5 (19–56)

0.02

Median (IQR) CRP, mg/dl (n = 315)

1.3 (0.5–3.6)

2 (0.5–4.4)

0.9 (0.5–3)

0.001

  1. ID inactive disease, IQR interquartile range, ANA antinuclear antibodies, ESR erythrocyte sedimentation rate, CRP C reactive protein
  2. #P value refers to the comparison between patients who did not achieve or achieved ID. §For the purposes of the study analyses, the ILAR categories of juvenile idiopathic arthritis were grouped in functional phenotypes according to Beukelman et al. (ref. [26])
  3. Data are the number (%) unless otherwise indicated