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Table 1 Characteristics of pediatric (n = 24) and adult (n = 10) patients with CNO

From: Chronic non-bacterial osteomyelitis: a comparative study between children and adults

Variable Pediatric patients, Value Adult patients, Value
Demographic characteristics
 Female, n (%) 14 (58.5%) 6 (60%)
 Age at diagnosis, yrs., median (range) 12.3 (7.9–18.9) 32.5 (22–56)
 Delay in diagnosis, yrs., median (range) 0.3 (0–12.9) 1.0 (0.4–17.1)
Clinical characteristics
 Arthritis 12 (50%) 3 (30%)
  - Arthritis distant to bone lesion 4 (16.7%) 1 (10%)
  - Sacroiliacal involvement, bilateral 6 (25%), 4 (16.7%) 1 (10%), 0
 Associated diseases 10 (41.5%) 5 (50%)
  - skin involvement 8 (33.3%) 4 (40%)
  - severe acne 7 (29.2%) 1 (10%)
  - pustolosis palmoplantaris 0 2 (20%)
  - psoriasis vulgaris 1 (4.2%) 0
  - hidradenitis suppurativa 0 1 (10%)
  - ocular involvement 3 (12.5%) 1 (10%)
  - coeliac disease 1 (4.2%) 0
Radiological characteristics
 Number of radiological lesions, mean 3.1 3.0
 median (range) 2 (1–7) 2 (1–9)
  - unifokal 10 (41.7%) 4 (40%)
 Clavicular involvement, sole 10 (41.7%), 7 (28.3%) 1 (10%), 0
 Sternal involvement 2 (8.3%) 5 (50%)
 Long bone metaphysis involvement 8 (33.3%) 1 (10%)
 Vertebral involvement 5 (20.8%) 5 (50%)
Histological characteristics
 Fibrosis, n (%) 16/16 (100%) 6/6 (100%)
 Chronic inflammation, n (%)
(Lymphocytes, plasmocytes, histiocytes)
16/16 (100%) 6/6 (100%)
 Acute inflammation, n (%) (Neutrophilic granulocytes) 8/16 (50%) 2/6 (33.3%)