Table 1 Characteristics of pediatric (n = 24) and adult (n = 10) patients with CNO
From: Chronic non-bacterial osteomyelitis: a comparative study between children and adults
Variable | Pediatric patients, Value | Adult patients, Value |
|---|---|---|
Demographic characteristics | ||
Female, n (%) | 14 (58.5%) | 6 (60%) |
Age at diagnosis, yrs., median (range) | 12.3 (7.9–18.9) | 32.5 (22–56) |
Delay in diagnosis, yrs., median (range) | 0.3 (0–12.9) | 1.0 (0.4–17.1) |
Clinical characteristics | ||
Arthritis | 12 (50%) | 3 (30%) |
- Arthritis distant to bone lesion | 4 (16.7%) | 1 (10%) |
- Sacroiliacal involvement, bilateral | 6 (25%), 4 (16.7%) | 1 (10%), 0 |
Associated diseases | 10 (41.5%) | 5 (50%) |
- skin involvement | 8 (33.3%) | 4 (40%) |
- severe acne | 7 (29.2%) | 1 (10%) |
- pustolosis palmoplantaris | 0 | 2 (20%) |
- psoriasis vulgaris | 1 (4.2%) | 0 |
- hidradenitis suppurativa | 0 | 1 (10%) |
- ocular involvement | 3 (12.5%) | 1 (10%) |
- coeliac disease | 1 (4.2%) | 0 |
Radiological characteristics | ||
Number of radiological lesions, mean | 3.1 | 3.0 |
median (range) | 2 (1–7) | 2 (1–9) |
- unifokal | 10 (41.7%) | 4 (40%) |
Clavicular involvement, sole | 10 (41.7%), 7 (28.3%) | 1 (10%), 0 |
Sternal involvement | 2 (8.3%) | 5 (50%) |
Long bone metaphysis involvement | 8 (33.3%) | 1 (10%) |
Vertebral involvement | 5 (20.8%) | 5 (50%) |
Histological characteristics | ||
Fibrosis, n (%) | 16/16 (100%) | 6/6 (100%) |
Chronic inflammation, n (%) (Lymphocytes, plasmocytes, histiocytes) | 16/16 (100%) | 6/6 (100%) |
Acute inflammation, n (%) (Neutrophilic granulocytes) | 8/16 (50%) | 2/6 (33.3%) |