From: Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies
Early onset – <  10 years of age | |
Suspected (e.g. recurrent infections) or proved immunodeficiency | |
Clinical features out of the typical clinical classification criteria for SLE | |
Severe, life-threatening or organ-threatening presentation | |
Aggressive course, rapid deterioration and/or accumulation of organ damage | |
Poor response to treatment | |
Familial cases | |
Consanguinity |