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Fig. 1 | Pediatric Rheumatology

Fig. 1

From: RAS-associated Autoimmune Leukoproliferative disease (RALD) manifested with early-onset SLE-like syndrome: a case series of RALD in Chinese children

Fig. 1

Direct sequencing of NRAS genes in different tissues from patients. Blood samples, oral mucosa cells, hair follicles, and nails were collected from each patient as well as blood samples from their parents, and sequenced. a Mutated NRAS gene (c.38G > A,p.G13D) was found only in the blood sample in Patient 1 as well as in saliva, which had a lower frequency of mutated allele. No mutation was found in either other tissues of Patient 1 or in blood of his parents. b Mutation of NRAS (c.37G > T, p.G13C) was only detected in blood of Patient 2, compared to the results of his other tissues and blood from his parents. c Mutated NRAS gene (c.38G > A,p.G13D) was found in the blood and nails of Patient 3 while NRAS genes in her hair follicles, oral mucosa as well as in her mother’s blood are all normal

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Pediatric Rheumatology

ISSN: 1546-0096