From: Hallmark trials in ANCA-associated vasculitis (AAV) for the pediatric rheumatologist
Study Group | Clinical Subgroup | Systemic Vasculitis Outside Ears, Nose, Throat and Lungs | Threatened Vital Organ Function | Other Definitions | Serum Creatinine (umol/L) |
---|---|---|---|---|---|
EUVAS | Localized | No | No | No constitutional symptoms, ANCA typically negative | < 120 |
Early Systemic | Yes | No | Constitutional symptoms present, ANCA-positive or negative | < 120 | |
Generalized | Yes | Yes | ANCA-positive | < 500 | |
Severe | Yes | Organ Failure | ANCA-positive | > 500 | |
Refractory | Yes | Yes | Refractory to standard therapy | Any | |
WGET Research Group | Limited | Allowed, but not required | No | Not severe | < 124, if hematuria, but no red blood cell casts present |
Severe | Yes | Yes | Organ- or life-threatening disease | Any |