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Table 1 Factors rated important in physician decisions regarding withdrawal of medications in inactive disease for systemic juvenile idiopathic arthritis (top 5 listed very important are bolded)

From: Physician practices for withdrawal of medications in inactive systemic juvenile arthritis, Childhood Arthritis and Rheumatology Research Alliance (CARRA) survey

Factor (N = 73)

Very Important

n (%)

Moderately Important

n (%)

Somewhat

Important

n (%)

Less

Important

n (%)

Un- important

n (%)

Patient/family preference

15 (21)

29 (40)

22 (30)

7 (9)

0

aToxicity/side effects/tolerance of medications

48 (65)

21 (28)

5 (7)

0

0

Poor adherence to medications

14 (19)

34 (47)

19 (26)

6 (8)

0

Younger age at diagnosis

3 (4)

8 (11)

23 (32)

31 (42)

8 (11)

bDuration of disease

8 (12)

35 (49)

13 (18)

13 (18)

2 (3)

Time maintained in inactive disease

38 (52)

29 (40)

5 (7)

1 (1)

0

cAmount of time to achieve inactive disease

24 (32)

36 (49)

12 (16)

2 (3)

0

cTotal number of DMARDs/ biologics used since diagnosis

19 (26)

29 (38)

13 (18)

11 (15)

2 (3)

Presence of JIA associated damage (joint or growth)

15 (21)

40 (56)

12 (16)

4 (6)

2 (3)

History of MAS

36 (50)

27 (37)

8 (11)

1 (1)

1 (1)

dHistory of previous cardiac or pulmonary involvement

29 (41)

24 (33)

15 (21)

3 (4)

1 (1)

History of previous ICU admission

20 (27)

34 (47)

14 (19)

3 (4)

2 (3)

Number of previous flares

33 (45)

25 (34)

13 (18)

2 (3)

0

dPast failure of medication taper

47 (65)

20 (28)

5 (7)

0

0

Anticipated social or environmental changes

1 (1)

30 (42)

27 (37)

14 (19)

1 (1)

  1. Abbreviations: N = Total number of responses for the specific factor
  2. a N = 74, b N = 71, c N = 74 d N = 72
  3. Other factors that physicians listed included: making plans for parenthood or discovery of pregnancy with intention to maintain pregnancy, new diagnoses, monitoring ESR/CRP/ferritin, financial considerations including coverage and amount of out-of-pocket payments, access to care, and season