TY - JOUR AU - Hospach, Toni AU - Glowatzki, Fabian AU - Blankenburg, Friederike AU - Conzelmann, Dennis AU - Stirnkorb, Christian AU - Müllerschön, Chris Sandra AU - von den Driesch, Peter AU - Köhler, Lisa Maria AU - Rohlfs, Meino AU - Klein, Christoph AU - Hauck, Fabian PY - 2019 DA - 2019/07/08 TI - Scoping review of biological treatment of deficiency of interleukin-36 receptor antagonist (DITRA) in children and adolescents JO - Pediatric Rheumatology SP - 37 VL - 17 IS - 1 AB - Deficiency of interleukin-36 receptor antagonist (DITRA) is a life threatening monogenic autoinflammatory disease caused by loss of function mutations in the IL36RN gene. Affected patients develop recurrent episodes of generalized pustular psoriasis (GPP) with systemic inflammation and fever. We here review and analyze the literature on pediatric DITRA patients who have been treated by biologicals targeting inflammatory cytokines. SN - 1546-0096 UR - https://doi.org/10.1186/s12969-019-0338-1 DO - 10.1186/s12969-019-0338-1 ID - Hospach2019 ER -