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Fig. 3 | Pediatric Rheumatology

Fig. 3

From: Retrospective case series describing the efficacy, safety and cost-effectiveness of a vial-sharing programme for canakinumab treatment for paediatric patients with cryopyrin-associated periodic syndrome

Fig. 3

CAPS disease activity score and Serum Amyloid A levels score pre-and post canakinumab. The difference between CAPS DAS and SAA scores before and after canakinumab was significant (P < 0.0001). Using these indices, minimally active disease was defined as absent or minimal disease activity (DAS ≤3/20 with no item scoring as severe) and normal markers of inflammation (SAA < 10 mg/L). The CAPS DAS and SAA (plus other routine investigations: full blood count, renal and liver function; and C-reactive protein) were assessed as a minimum every 2 months from commencement of treatment. On canakinumab, 19/20 (95%) patients had a CAPS DAS ≤ 3 (Fig. 1); and 14/20 (70%) patients had a SAA of < 10 mg/L (Fig. 2). After canakinumab treatment, 15/20 (75%) patients had CAPS DAS ≤ 3 and a SAA < 10 mg/L (Fig. 3)

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