Table 1 (abstract P1065). TBK1 phosphorylation assessed by flow-cytometry after infection with different MOI (20, 120, 400) of E. coli, single stimulation with LPS (0.5 ug/ml), cGAMP (20 ug/ml) and Poly(I:C) (20 ug/ml), and combined stimulation of cGAS/TBK1 and TLRs pathways (cGAMP + LPS; cGAMP + Poly(I:C); Poly(I:C) + LPS)
From: 10th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID)
| Â | pTBK1 (MFI) Healthy control fibros | pTBK1 (MFI) DNase2 mut fibros |
|---|---|---|
NS | 2.9 | 3 |
E.coli MOI 120 | 3.1 | 7 |
E.coli MOI 400 | 3.7 | 8 |
LPS | 2.3 | 6.1 |
cGAMP | 3.3 | 4.3 |
Poly(I:C) | 3.4 | 5.6 |
cGAMP + LPS | 4.5 | 7.5 |
cGAMP + Poly(I:C) | 4.5 | 7.6 |
Poly(I:C) + LPS | 2.8 | 4.4 |