From: 10th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID)
Patients | Mutation | Clinical features | Laboratory features | Response to therapy |
---|---|---|---|---|
1 | A230T | Recurrent fever, acne, cutaneous abscesses, pyogenic arthritis | ←CRP,ESR,SAA | Anti-TNF |
2 | A230T | Acne, pyogenic arthritis | ←CRP,ESR,SAA | Anti-TNF |
3 | R405C | Recurrent fever | ← CRP,ESR,SAA, Zinc | / |
4 | D266N | Recurrent fever | ←CRP,ESR,SAA, Zinc | / |
5 | E250K | Acne, psoriasis, pyogenic arthritis, hepatosplenomegaly | ←CRP,ESR,SAA, Zinc, serum calprotectin | / |
6 | E250K | pyogenic arthritis,hepato- splenomegaly | ←CRP,ESR,SAA, Zinc, serum calprotectin | IL-1 inhibition |
7 | E250K | Limphnode abscess, hepatosplenomegaly | ←CRP,ESR,SAA | / |