From: 10th Congress of International Society of Systemic Auto-Inflammatory Diseases (ISSAID)
Case | Maternal Age at pregnancy | Anakinra Relation to pregnancy | USGs | Weeks at delivery | Gender of the baby/fetus | Mode of the delivery | 1st minute APGAR | Follow-up duration after birth (months) | Complications after birth |
---|---|---|---|---|---|---|---|---|---|
1 | 28 | started at 12th Gestational Week (GW) and used until birth | normal | Birth at 40th GW | girl | vaginal | 10 | 34 mo | No |
2 | 31 | Conceived on Anakinra (have been on Anakinra since 2012), discontinued at 29th GW, reintroduced at 33th GW due to symptom flare. | normal | Birth at 38th GW | boy | C/S | 6 | 48 mo | Methicillin-Sensitive Staphylococcus Aureus incision-site infection (treated with Tygecycline) in mother |
3 | 24 | started at 15th GW and useduntil birth | normal | Birth at 38th GW | boy | Vaginal | 8 | 48 mo | thrombocyte count of the baby was low (23,000/mm3) (After three courses of IVIG, it was increased to 95,000/mm3 and a month later to 269,000/mm3) |
4 | 32 | started at 16th GW, continued for 6 months following the birth at 31th GW | normal | Birth at 31th GW | 2 girls | C/S | 8 for both babies | 42 mo | No |
5 | 25 | Started at 23th GW used until birth at 37th GW | normal | Birth at 37th GW | girl | C/S | 7 | 42 mo | Injection site reaction |
6 | 29 | Started at 32nd GW, used until birth 40 th GW | normal | Birth at 40th GW | Girl | C/S | ? | 37 mo | No |
7 | 33 | Started at 2013, conceived under Anakinra. Anakinra was stopped at the first month of pregnancy, she flared and it was reintroduced. | Normal | Birth at 38th GW | Girl | C/S | 8 | 42 mo | No |
8 | 30 | Started at 34th GW, used until still birth at 37th GW | Intrauterine death at 37th GW | Pregnancy terminated at 37th GW | Boy | Normal | 0 | 10 mo | No |
9 | Zeynep | Started at 6th GW, still using after birth | Normal | Birth at 36th GW | Girl | C/S | 9 | 9 mo | No |