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Table 2 The Oxford classification of IgA nephropathy (according to ref. [28])

From: Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?

Histological variable

Description

Mesangial hypercellularity

M0 < 50% of glomeruli showing mesangial hypercellularity

M1 > 50% of glomeruli showing mesangial hypercellularity

Endocapillary hypercellularity

E0 absent

E1 present

Segmental glomerulosclerosis/adhesion

S0 absent

S1 present

presence or absence of podocyte hypertrophy/tip lesions in biopsies with S1

Tubular atrophy/interstitial fibrosis

T0 ≤ 25% of the cortical area affected by tubular atrophy or interstitial fibrosis

T1 26–50% of the cortical area affected by tubular atrophy or interstitial fibrosis

T2 > 50% of the cortical area affected by tubular atrophy or interstitial fibrosis

Cellular/fibrocellular crescents

C0 absent

C1 present in at least one glomerulus

C2 present in > 25% of glomeruli

  1. Modified with permission from Elsevier Ltd.©