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Table 3 Differences in primary and secondary outcomes at 3 and 12 months

From: The effectiveness of a multidisciplinary intervention strategy for the treatment of symptomatic joint hypermobility in childhood: a randomised, single Centre parallel group trial (The Bendy Study)

Factor Standard care Intervention Unadjusted mean difference p-value Adjusted mean difference p-value
3 Months change from baseline (outcome – baseline)
 Child’s pain assessment, mean (SD) −1.33 (1.69) −0.73 (1.55) 0.6 (− 0.02,1.22) 0.058 0.62 (0.04,1.21) 0.038
 Parent’s pain assessment mean (SD) −6.73 (26.26) −3.27 (28.64) 3.46 (−6.88,13.8) 0.509 3.36 (−7.01,13.72) 0.522
 Parent’s reported physical function, mean (SD) −0.02 (0.38) 0.13 (0.52) 0.15 (−0.02,0.33) 0.088 0.15 (−0.02,0.32) 0.089
 Child reported HRQoL, mean (SD) 0.00 (0.10) 0.01 (0.11) 0.01 (−0.03,0.05) 0.493 0.01 (−0.03,0.05) 0.492
 Coordination, mean (SD) 7.57 (20.26) 6.21 (19.54) −1.36 (−8.88,6.16) 0.721 −1.36 (−8.92,6.19) 0.721
 Grip strength, mean (SD) 2.32 (12.03) 1.12 (13.87) −1.2 (−6.18,3.78) 0.634 −1.21 (− 6.19,3.77) 0.632
12 Months change from baseline (outcome – baseline)
 Child’s pain assessment, mean (SD) −1.58 (1.92) −1.57 (1.53) 0.01 (−0.66,0.69) 0.967 0.06 (−0.6,0.71) 0.862
 Parent’s pain assessment mean (SD) −7.25 (29.50) −6.81 (27.30) 0.44 (−10.55,11.43) 0.937 −0.08 (−10.94,10.78) 0.988
 Parent-reported physical function, mean (SD) −0.02 (0.38) 0.04 (0.55) 0.06 (−0.12,0.24) 0.522 0.06 (−0.13,0.24) 0.546
 Child reported HRQoL, mean (SD) −0.00 (0.12) 0.02 (0.09) 0.02 (−0.02,0.06) 0.244 0.03 (−0.02,0.07) 0.222
 Coordination, mean (SD) 10.75 (19.46) 3.83 (20.75) −6.92 (−14.76,0.92) 0.083 −6.87 (− 14.75,1.02) 0.087
 Grip strength, mean (SD) 7.29 (16.05) 4.72 (17.16) −2.58 (−9.05,3.89) 0.431 −2.59 (−9.1,3.92) 0.432