Skip to main content

Advertisement

Table 3 Laboratory data of siblings II-1 and II-2 at initial presentation, at relapse of disease requiring ofatumumab infusion and at follow-up 8 months after ofatumumab infusion

From: Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ

Investigations Patient II-1 (reference range) Patient II-2 (reference range)
At presentation At relapse 8 months after ofatumumab At presentation At relapse 8 months after ofatumumab
FBC × 10^12/L (RR 4.00–5.20) 3.88 3.92 4.76 3.6 3.01 5.26
Hb g/L (RR 115–145) 96 102 118 97 73 128
Platelets × 10^9/L (RR 150–450) 85 5 209 13 63 397
WCC × 10^9/L (RR 0.0–10.0) 5.94 6.54 6.58 9.60 2.78 7.83
Lymphocytes × 10^9/L (1.5–7.0) 1.79 1.69 1.65 1.70 0.48 1.86
Neutrophils × 10^9/L (RR 1.5–8.0) 2.17 4.20 1.83 1.01 2.23 4.90
CD 19 lymphocyte subset % 21.0 not assessed 0.0 25.0 23.7 0.5
CD 3 lymphocyte subset % 73.0 not assessed 97.5 65.0 83.0 96.0
CD 16+ CD 56+ lymphocyte subset % 4.0 not assessed 1.7 8.0 5.0 0.7
CD 3+ CD 56+ lymphocyte subset % 0.2 not assessed not assessed 0.2 0.8 not assessed
CD 3+ CD4+ lymphocyte subset % 46.0 not assessed 49.7 32.0 38.0 41.5
CD 3+ CD 8+ lymphocyte subset % 21.0 not assessed 40.6 37.0 37.0 42.2
ESR mm/hr. (RR 0–10) 128 132 50 130 75 1
CRP mg/L (RR < 20) 21 19 < 5 28 21 < 5
Urea 3.4 3.9 3.4 4.8 7.8 4.1
Creatinine umol/L (RR 28–57) 36 25 40 33 83 52
Urine creatinine mmol/L 3.4 1.5 3.5 2.8 1.1 0.5
Urine albumin/creatinine ratio mg/mmol (RR 0.2–4.5) 1.5 5.3 3.1 8.9 1.1 not assessed
Urine NAG/creatinine ratio units/mmol (RR 2–20) not assessed not assessed 4 not assessed 67 74
Urine retinol binding protein ug/L not assessed not assessed 39 not assessed not assessed 161
Urine retinol/creatinine ratio ug/mmol (RR 5–41) not assessed not assessed 11 not assessed not assessed 85
ANA 1:1280 not assessed 1:640 Negative not assessed not assessed
Anti-DNA IU/ml (RR 0–9.9) 65 66 16 43 16 4.8
IgG G/L (RR 5.4–16.1) 16.8 22.3 7.66 21.9 18.5 7.12
IgA G/L (RR 0.5–2.4) 2.19 2.35 1.15 2.69 3.34 1.72
IgM G/L (RR 0.5–1.8) 1.63 1.31 0.35 2.90 2.36 0.86
C3 G/L (RR 0.75–1.65) 0.83 0.41 1.51 0.64 0.91 1.37
C4 G/L (RR 0.14–0.54) 0.10 0.03 0.19 0.08 0.15 0.29
  1. RR Reference range, FBC Full blood count, Hb haemoglobin, WCC White cell count, ESR Erythrocyte sedimentation rate, CRP C reactive protein, NAG Nitrosaminoglycan, DNA deoxyribonucleic acid