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Table 1 Systemic Lupus International Collaborating Clinics (SLICC) criteria and the presence (√) or absence (x) for each affected sibling [25]

From: Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δ

 

II-1

II-2

II-3

Acute cutaneous lupus

Chronic cutaneous lupus

x

x

x

Oral or nasal ulcers

x

x

Non-scarring alopecia

Arthritis

x

x

x

Serositis

x

x

Renal

x

x

Neurologic

x

x

x

Haemolytic anaemia

Leukopenia

x

Thrombocytopenia

ANA (above lab range)

Anti-dsDNA(above lab range)

Anti-Sm

x

x

Anti-phospholipid antibody

x

Low complement

Direct Coombs’ test

not assessed

not assessed

not assessed

  1. WCC White cell count, ANA Anti-nuclear antibodies, ds-DNA Double-stranded deoxyribonucleic acid, Sm Smith. To fulfil these classification criteria, 4 or more criteria must be present (including at least one clinical and one immunological feature), or biopsy proven lupus nephritis with positive ANA or anti-DNA antibodies