Fig. 1From: Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C δPedigree of the family and renal histology. a The affected siblings (shaded) are homozygous for the PRKCD mutation as indicated and the parents are carriers of the mutation. WT, wild type. b Low power (Periodic acid–Schiff stain, original magnification × 40) and Fig. 1c higher power (Haematoxylin and Eosin stain, original magnification × 200) showing severe acute tubulointerstitial nephritis with marked predominantly mononuclear inflammatory infiltrate and associated mild acute tubular damageBack to article page