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Table 2 Characteristics of patients’ with initial echocardiogram prior to immunoglobulin infusion according to the response to immunoglobulin infusion (N=58)

From: Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions

  Resistant (N = 16)
N (%)
Responder (N = 42)
N (%)
p
Demographics    
 Sex (M/F) 9/7 24/18 1
 Age (mean) 33 29 0.32
 < 12 months 8 (50) 11 (26) 0.12
 12–23 months 1 (6) 10 (24) 0.26
 ≥ 24 months 7 (44) 21 (50) 0.77
Clinics
 Fever length before Ig (days) 6 [5–8] 7 [6–8] .35
 Lymphadenopathy 7 (44) 17 (40) 1
 Rash 11 (69) 32 (76) .74
 Conjunctivitis 12 (75) 25 (60) .37
 Enanthem 8 (50) 30 (71) .14
 Modification of the extremities 5 (31) 22 (52) .24
 Fever length after Ig (hours) 62 [58–64] 24 [20–36] <  10−10
Biology
Platelets 463,500 405,900 .61
Neutrophils (%) 66 64 .47
Hemoglobin (g/dl) 10.3 10.3 .91
 CRP (mg/L) 172 140 .23
 ΔCRP (%) 48 62 .08
 ASAT (UI/L) 46 61 .31
 ALAT (UI/L) 49 81 .15
 Bilirubin (μmol/L) 17 10 .54
 LDH (UI/L) 855 636 .66
 Albumin (g/L) 26 27 .96
 Sodium (mmol/L) 136 136 .70
Scores
 Kobayashi    .66
  <  5 10 (91) 29 (81)  
  ≥ 5 1 (9) 7 (19)  
 Egami    1
  < 3 9 (75) 26 (72)  
  ≥ 3 3 (25) 10 (28)  
 Sano    .69
  < 2 5 (63) 23 (70)  
  ≥ 2 3 (37) 10 (30)  
Treatments
 1st dose IV Ig 15 (100) 43 (100) 1
 2nd dose IV Ig 5 (33) 0 (0) .0009
 Corticosteroids 5 (33) 1 (2) .004
First echocardiogram results
 Normal 4 (25) 25 (60) .04
 Abnormal 12 (75) 17 (40) .04
 Coronary artery dilatation 4 (25) 5 (12) .24
 Pericardial effusion 3 (19) 6 (14) .70
 Perivascular brightness of the coronary arteries 1 (7) 2 (5) .53
 CAA 1 (7) 2 (5) .53
  Small (<  5 mm) 0 1  
  Median (5–8 mm) 0 1  
  Giant (>  8 mm) 1 0  
 Left ventricular dysfunction 1 2  
  Mitral insufficiency 0 0  
Abnormal late echocardiograms
 6 weeks 8 (50) 5 (12) .03
  Coronary artery dilatation 5 (31) 1 (2) .004
  Pericardial effusion 1 (7) 0 .28
  Perivascular brightness of the coronary arteries 0 0 1
  CAA 2 (13) 4 (9) .66
   Small (<  5 mm) 0 2  
   Median (5–8 mm) 1 2  
   Giant (>  8 mm) 1 0  
 Long-term 3 (19) 2 (5) .12
  Coronary artery dilatation 2 0  
   CAA 1 2  
   Small (<  5 mm) 1 2  
   Median (5–8 mm) 0 0  
  1. Sole p-values < 0.05 are in boldfaced and p-values = 0.05 are not in boldfaced