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Table 2 Characteristics of patients’ with initial echocardiogram prior to immunoglobulin infusion according to the response to immunoglobulin infusion (N=58)

From: Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions

 

Resistant (N = 16)

N (%)

Responder (N = 42)

N (%)

p

Demographics

   

 Sex (M/F)

9/7

24/18

1

 Age (mean)

33

29

0.32

 < 12 months

8 (50)

11 (26)

0.12

 12–23 months

1 (6)

10 (24)

0.26

 ≥ 24 months

7 (44)

21 (50)

0.77

Clinics

 Fever length before Ig (days)

6 [5–8]

7 [6–8]

.35

 Lymphadenopathy

7 (44)

17 (40)

1

 Rash

11 (69)

32 (76)

.74

 Conjunctivitis

12 (75)

25 (60)

.37

 Enanthem

8 (50)

30 (71)

.14

 Modification of the extremities

5 (31)

22 (52)

.24

 Fever length after Ig (hours)

62 [58–64]

24 [20–36]

<  10−10

Biology

Platelets

463,500

405,900

.61

Neutrophils (%)

66

64

.47

Hemoglobin (g/dl)

10.3

10.3

.91

 CRP (mg/L)

172

140

.23

 ΔCRP (%)

48

62

.08

 ASAT (UI/L)

46

61

.31

 ALAT (UI/L)

49

81

.15

 Bilirubin (μmol/L)

17

10

.54

 LDH (UI/L)

855

636

.66

 Albumin (g/L)

26

27

.96

 Sodium (mmol/L)

136

136

.70

Scores

 Kobayashi

  

.66

  <  5

10 (91)

29 (81)

 

  ≥ 5

1 (9)

7 (19)

 

 Egami

  

1

  < 3

9 (75)

26 (72)

 

  ≥ 3

3 (25)

10 (28)

 

 Sano

  

.69

  < 2

5 (63)

23 (70)

 

  ≥ 2

3 (37)

10 (30)

 

Treatments

 1st dose IV Ig

15 (100)

43 (100)

1

 2nd dose IV Ig

5 (33)

0 (0)

.0009

 Corticosteroids

5 (33)

1 (2)

.004

First echocardiogram results

 Normal

4 (25)

25 (60)

.04

 Abnormal

12 (75)

17 (40)

.04

 Coronary artery dilatation

4 (25)

5 (12)

.24

 Pericardial effusion

3 (19)

6 (14)

.70

 Perivascular brightness of the coronary arteries

1 (7)

2 (5)

.53

 CAA

1 (7)

2 (5)

.53

  Small (<  5 mm)

0

1

 

  Median (5–8 mm)

0

1

 

  Giant (>  8 mm)

1

0

 

 Left ventricular dysfunction

1

2

 

  Mitral insufficiency

0

0

 

Abnormal late echocardiograms

 6 weeks

8 (50)

5 (12)

.03

  Coronary artery dilatation

5 (31)

1 (2)

.004

  Pericardial effusion

1 (7)

0

.28

  Perivascular brightness of the coronary arteries

0

0

1

  CAA

2 (13)

4 (9)

.66

   Small (<  5 mm)

0

2

 

   Median (5–8 mm)

1

2

 

   Giant (>  8 mm)

1

0

 

 Long-term

3 (19)

2 (5)

.12

  Coronary artery dilatation

2

0

 

   CAA

1

2

 

   Small (<  5 mm)

1

2

 

   Median (5–8 mm)

0

0

 
  1. Sole p-values < 0.05 are in boldfaced and p-values = 0.05 are not in boldfaced
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Pediatric Rheumatology

ISSN: 1546-0096