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Table 1 (abstract P45). See text for description

From: Proceedings of the 2018 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting

  TCZ SC
(WA28118)
TCZ IV
(WA18221)
  <30 kg TCZ
162 mg Q2W
n = 25
≥30 kg TCZ
162 mg QW
n = 26
<30 kg TCZ
12 mg/kg Q2W
n = 46
≥30 kg TCZ
8 mg/kg Q2W
n = 43
Model-computed steady state PK parameters, median (range)
Cmin,ss μg/mL 64.2
(16.6-135.9)
72.4
19.5-157.8)
65.9
(19.0-135.5)
70.7
(5.3-126.6)
Cmax,ss μg/mL 126.6
(51.7-265.8)
89.8
(26.4-190.2)
274.4
(148.8-444.0)
253.0
(119.6-404.3)
AUC2weeks,ss μg/mL×day 1298
(539-2792)
1154
(334-2370)
1734
(840-2712)
1631
(526-2779)