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Table 1 Clinical symptoms and demographic features children

From: Clinical study of children with cryofibrinogenemia: a retrospective study from a single center

Case 1 2 (primary) 3 4 5 6 7 8 Total
Sex M F F F M F F F Female/male ratio 3:1
Age of onset (yrs) 9.4 13.6 11.4 9.6 2.5 12.4 18.5 14.6 Mean (SD) age at on set (yrs) 10.3 ± 4.6
Age at diagnosis (yrs) 9.6 13.8 11.6 10.6 4 13.6 18.6 17.1 Mean (SD) at diagnosis (yrs) 12.3 ± 4
Expired on (yrs) 10.4 Loss to follow up 12.1 10.8 (−) (−) 19 17.6  
Clinical symptoms All patients
Initial/Total Initial, n Total, n
 Myalgia (+) (+) (+) (+) (+) (+) (+) (+) (−) (−) (−) (+) (−) (+) (+) (+) 5 7
 Fever (−) (+) (−) (+) (−) (+) (−) (−) (−) (−) (−) (−) (−) (+) (−) (−) 0 4
 Arthralgia (+) (+) (+) (+) (+) (+) (+) (+) (+) (+) (+) (+) (−) (+) (+) (+) 7 8
Skin manifestations
 Purpura (−) (+) (+) (+) (−) (+) (+) (+) (−) (+) (−) (+) (+) (+) (−) (+) 3 8
 Raynaud phenomenon (−) (+) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) 0 1
 Skin necrosis or ulceration (−) (+) (−) (−) (−) (+) (−) (−) (+) (+) (−) (−) (−) (+) (−) (+) 1 5
 Livedo reticularis (−) (+) (−) (−) (+) (+) (−) (−) (−) (−) (−) (−) (−) (+) (−) (−) 1 3
 Urticaria (−) (−) (+) (+) (−) (−) (−) (−) (−) (−) (−) (−) (−) (+) (+) (+) 2 3
 Gangrene (−) (+) (−) (−) (−) (+) (−) (−) (−) (−) (−) (−) (−) (+) (−) (+) 0 4
 Sensitivity to cold (−) (−) (+) (+) (−) (−) (−) (+) (−) (−) (−) (+) (−) (+) (−) (+) 1 5
 Ecchymosis (−) (+) (−) (−) (−) (+) (−) (+) (−) (+) (−) (+) (+) (+) (−) (+) 1 7
Neurological involvement
 Muscle weakness (+) (+) (−) (+) (+) (+) (+) (+) (−) (+) (−) (+) (−) (+) (−) (+) 3 8
 Numbness (−) (+) (−) (−) (−) (+) (−) (+) (−) (−) (−) (+) (−) (+) (−) (+) 0 6
 Headache (−) (+) (−) (+) (+) (+) (−) (+) (−) (−) (+) (+) (+) (+) (+) (+) 4 7
 Vertigo (−) (−) (−) (+) (−) (+) (−) (−) (−) (−) (−) (+) (−) (+) (+) (+) 1 5
 Dizziness (−) (+) (−) (+) (+) (+) (−) (+) (−) (−) (+) (+) (+) (+) (+) (+) 4 7
 Seizure (−) (−) (−) (−) (−) (+) (−) (−) (−) (−) (−) (−) (−) (+) (−) (+) 0 3
 Blurred vision (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (+) (+) (+) (−) (+) 1 3
 Urinary retention (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (+) 0 1
Others
 Dyspnea (+) (+) (−) (−) (+) (+) (−) (+) (−) (+) (−) (+) (−) (+) (−) (+) 2 7
 Chest pain (+) (+) (−) (−) (+) (+) (−) (+) (−) (+) (−) (+) (−) (+) (−) (+) 2 7
 Abdominal pain (+) (+) (−) (+) (+) (+) (−) (−) (−) (+) (+) (+) (−) (+) (−) (+) 3 7
 Hematochezia (−) (−) (−) (−) (−) (−) (−) (−) (−) (+) (−) (+) (−) (−) (−) (+) 0 3
 Menorrhea (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (+) 0 1
 Bone pain (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (−) (+) (+) 1 1
 Insomnia (−) (+) (−) (+) (−) (−) (−) (−) (−) (−) (−) (+) (−) (+) (−) (+) 0 5