TY - JOUR AU - Bruck, N. AU - Schnabel, A. AU - Hedrich, C. M. PY - 2015 DA - 2015// TI - Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (SJIA) and target-directed therapeutic approaches JO - Clin Immunol VL - 159 UR - https://doi.org/10.1016/j.clim.2015.04.018 DO - 10.1016/j.clim.2015.04.018 ID - Bruck2015 ER - TY - JOUR AU - Woo, P. PY - 2006 DA - 2006// TI - Systemic juvenile idiopathic arthritis: diagnosis, management, and outcome JO - Nat Clin Pract Rheumatol VL - 2 UR - https://doi.org/10.1038/ncprheum0084 DO - 10.1038/ncprheum0084 ID - Woo2006 ER - TY - JOUR AU - DeWitt, E. M. AU - Kimura, Y. AU - Beukelman, T. PY - 2012 DA - 2012// TI - Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis JO - Arthritis Care Res (Hoboken) VL - 64 ID - DeWitt2012 ER - TY - STD TI - Martini, A. PRINTO classification for SJIA: oral presentation: toward a new classification of JIA, in PRES annual meeting. 2016: Genoa, Italy. ID - ref4 ER - TY - JOUR AU - Hinze, C. H. AU - Holzinger, D. AU - Lainka, E. PY - 2018 DA - 2018// TI - Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany JO - Pediatr Rheumatol Online J VL - 16 UR - https://doi.org/10.1186/s12969-018-0224-2 DO - 10.1186/s12969-018-0224-2 ID - Hinze2018 ER - TY - JOUR AU - Grom, A. A. AU - Horne, A. AU - De Benedetti, F. PY - 2016 DA - 2016// TI - Macrophage activation syndrome in the era of biologic therapy JO - Nat Rev Rheumatol VL - 12 UR - https://doi.org/10.1038/nrrheum.2015.179 DO - 10.1038/nrrheum.2015.179 ID - Grom2016 ER - TY - JOUR AU - Woerner, A. AU - von Scheven-Gête, A. AU - Cimaz, R. PY - 2015 DA - 2015// TI - Complications of systemic juvenile idiopathic arthritis: risk factors and management recommendations JO - Expert Rev Clin Immunol VL - 11 UR - https://doi.org/10.1586/1744666X.2015.1032257 DO - 10.1586/1744666X.2015.1032257 ID - Woerner2015 ER - TY - JOUR AU - Tarp, S. AU - Amarilyo, G. AU - Foeldvari, I. PY - 2016 DA - 2016// TI - Efficacy and safety of biological agents for systemic juvenile idiopathic arthritis: a systematic review and meta-analysis of randomized trials JO - Rheumatology (Oxford) VL - 55 UR - https://doi.org/10.1093/rheumatology/kev382 DO - 10.1093/rheumatology/kev382 ID - Tarp2016 ER - TY - JOUR AU - Yokota, S. AU - Tanaka, T. AU - Kishimoto, T. PY - 2012 DA - 2012// TI - Efficacy, safety and tolerability of tocilizumab in patients with systemic juvenile idiopathic arthritis JO - Ther Adv Musculoskelet Dis VL - 4 UR - https://doi.org/10.1177/1759720X12455960 DO - 10.1177/1759720X12455960 ID - Yokota2012 ER - TY - JOUR AU - Ruperto, N. AU - Brunner, H. PY - 2012 DA - 2012// TI - Two randomized trials of Canakinumab in systemic juvenile idiopathic arthritis JO - N Engl J Med VL - 367 UR - https://doi.org/10.1056/NEJMoa1205099 DO - 10.1056/NEJMoa1205099 ID - Ruperto2012 ER - TY - JOUR AU - Ruperto, N. AU - Quartier, P. AU - Wulffraat, N. PY - 2012 DA - 2012// TI - A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features JO - Arthritis Rheum VL - 64 UR - https://doi.org/10.1002/art.33342 DO - 10.1002/art.33342 ID - Ruperto2012 ER - TY - JOUR AU - De Benedetti, F. AU - Brunner, H. I. AU - Ruperto, N. PY - 2012 DA - 2012// TI - Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis JO - N Engl J Med VL - 367 UR - https://doi.org/10.1056/NEJMoa1112802 DO - 10.1056/NEJMoa1112802 ID - De Benedetti2012 ER - TY - JOUR AU - Barone, P. AU - Pignataro, R. AU - Garozzo, M. T. PY - 2016 DA - 2016// TI - IL-6 blockers in systemic onset juvenile idiopathic arthritis JO - Immunotherapy VL - 8 UR - https://doi.org/10.2217/imt.15.104 DO - 10.2217/imt.15.104 ID - Barone2016 ER - TY - JOUR AU - Klotsche, J. AU - Raab, A. AU - Niewerth, M. PY - 2016 DA - 2016// TI - Outcome and Trends in Treatment of Systemic Juvenile Idiopathic Arthritis in the German National Pediatric Rheumatologic Database, 2000-2013 JO - Arthritis Rheumatol VL - 68 UR - https://doi.org/10.1002/art.39796 DO - 10.1002/art.39796 ID - Klotsche2016 ER - TY - JOUR AU - Lainka, E. AU - Bielak, M. AU - Hilger, V. PY - 2011 DA - 2011// TI - Translational research network and patient registry for auto-inflammatory diseases JO - Rheumatology (Oxford) VL - 50 UR - https://doi.org/10.1093/rheumatology/keq270 DO - 10.1093/rheumatology/keq270 ID - Lainka2011 ER - TY - JOUR AU - Wallace, C. A. AU - Ruperto, N. AU - Giannini, E. PY - 2004 DA - 2004// TI - Preliminary criteria remission for select categories of juvenile idiopathic arthritis JO - J Rheumatol VL - 31 ID - Wallace2004 ER - TY - JOUR AU - Petty, R. E. AU - Southwood, T. R. AU - Manners, P. PY - 2004 DA - 2004// TI - International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001 JO - J Rheumatol VL - 31 ID - Petty2004 ER - TY - JOUR AU - Kumar, S. AU - Kunhiraman, D. S. AU - Rajam, L. PY - 2012 DA - 2012// TI - Application of the Yamaguchi criteria for classification of “suspected” systemic juvenile idiopathic arthritis (SJIA) JO - Pediatr Rheumatol VL - 10 UR - https://doi.org/10.1186/1546-0096-10-40 DO - 10.1186/1546-0096-10-40 ID - Kumar2012 ER - TY - JOUR AU - Martini, A. PY - 2012 DA - 2012// TI - It is time to rethink juvenile idiopathic arthritis classification and nomenclature JO - Ann Rheum Dis VL - 71 UR - https://doi.org/10.1136/annrheumdis-2012-201388 DO - 10.1136/annrheumdis-2012-201388 ID - Martini2012 ER - TY - JOUR AU - Yamaguchi, M. AU - Ohta, A. AU - Tsunematsu, T. PY - 2001 DA - 2001// TI - Preliminary criteria for classification of adult Still’s disease JO - J Rheumatol VL - 19 ID - Yamaguchi2001 ER - TY - BOOK AU - Forster, J. AU - Weigt-Usinger, K. AU - Lücke, T. PY - 2015 DA - 2015// TI - Classical Hodgkin lymphoma in a 10-year-old girl with systemic-onset juvenile idiopathic arthritis under IL-6 inhibition (tocilizumab) ID - Forster2015 ER - TY - JOUR AU - Pfeil, J. AU - Grulich-Henn, J. AU - Wenning, D. PY - 2014 DA - 2014// TI - Multiple upper gastrointestinal perforations in a 15-year-old patient treated with tocilizumab JO - Rheumatology (Oxford) VL - 53 UR - https://doi.org/10.1093/rheumatology/keu032 DO - 10.1093/rheumatology/keu032 ID - Pfeil2014 ER - TY - JOUR AU - Yokota, S. AU - Miyamae, T. AU - Imagawa, T. PY - 2005 DA - 2005// TI - Clinical study of Tocilizumab in children with systemic-onset juvenile idiopathic arthritis JO - Clin Rev Allergy Immunol VL - 28 UR - https://doi.org/10.1385/CRIAI:28:3:231 DO - 10.1385/CRIAI:28:3:231 ID - Yokota2005 ER - TY - JOUR AU - Horneff, G. AU - Schulz, A. C. AU - Klotsche, J. PY - 2017 DA - 2017// TI - Experience with etanercept, tocilizumab and interleukin-1 inhibitors in systemic onset juvenile idiopathic arthritis patients from the BIKER registry JO - Arthritis Res Ther VL - 19 UR - https://doi.org/10.1186/s13075-017-1462-2 DO - 10.1186/s13075-017-1462-2 ID - Horneff2017 ER - TY - JOUR AU - Brunner, H. I. AU - Ruperto, N. AU - Zuber, Z. PY - 2015 DA - 2015// TI - Efficacy and safety of Tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial JO - Ann Rheum Dis VL - 74 UR - https://doi.org/10.1136/annrheumdis-2014-205351 DO - 10.1136/annrheumdis-2014-205351 ID - Brunner2015 ER - TY - STD TI - Yokota S, Itoh Y, Morio T et al. Tocilizumab in systemic juvenile idiopathic arthritis in a real-world clinical setting: results from 1 year of postmarketing surveillance follow-up of 417 patients in Japan. Ann Rheum Dis. 2015. doi: https://doi.org/10.1136/annrheumdis-2015-207818. [Epub ahead of print]. pii: annrheumdis-2015-207818. ID - ref26 ER - TY - STD TI - Woerner A, Uettwiller F, Melki I et al. Biological treatment in systemic juvenile idiopathic arthritis: achievement of inactive disease or clinical remission on a first, second or third biological agent. RMD Open 2015; 1(1):e000036. doi: https://doi.org/10.1136/rmdopen-2014-000036. eCollection 2015. ID - ref27 ER - TY - STD TI - Kostik MM, Isupova EA, Chikova IA, et al. Reasons for inactive disease and flare in systemic onset juvenile idiopathic arthritis patients during tocilizumab treatment. Clin Exp Rheumatol. 2017; ID - ref28 ER - TY - JOUR AU - Haas, P. PY - 2011 DA - 2011// TI - Systemic onset juvenile idiopathic arthritis – at the borderline between Autoinflammation and autoimmunity JO - Akt Rheumatol VL - 36 UR - https://doi.org/10.1055/s-0031-1275747 DO - 10.1055/s-0031-1275747 ID - Haas2011 ER - TY - JOUR AU - Hügle, B. AU - Hinze, C. AU - Lainka, E. AU - Fischer, N. AU - Haas, J. P. PY - 2014 DA - 2014// TI - Development of positive antinuclear antibodies and rheumatoid factor in systemic juvenile idiopathic arthritis points toward an autoimmune phenotype later in the disease course JO - Pediatr Rheumatol Online J VL - 12 UR - https://doi.org/10.1186/1546-0096-12-28 DO - 10.1186/1546-0096-12-28 ID - Hügle2014 ER - TY - JOUR AU - Singh-Grewal, D. AU - Schneider, R. AU - Bayer, N. AU - Feldman, B. M. PY - 2006 DA - 2006// TI - Predictors of disease course and remission in systemic juvenile idiopathic arthritis: significance of early clinical and laboratory features JO - Arthritis Rheum VL - 54 UR - https://doi.org/10.1002/art.21774 DO - 10.1002/art.21774 ID - Singh-Grewal2006 ER - TY - JOUR AU - Kearsley-Fleet, L. AU - Davies, R. AU - Baildam, E. PY - 2016 DA - 2016// TI - Factors associated with choice of biologic among children with juvenile idiopathic arthritis: results from two UK paediatric biologic registers JO - Rheumatology (Oxford) VL - 55 UR - https://doi.org/10.1093/rheumatology/kev429 DO - 10.1093/rheumatology/kev429 ID - Kearsley-Fleet2016 ER - TY - JOUR AU - Gattorno, M. AU - Piccini, A. AU - Lasigliè, D. PY - 2008 DA - 2008// TI - The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.23437 DO - 10.1002/art.23437 ID - Gattorno2008 ER - TY - JOUR AU - Vastert, S. J. AU - de Jager, W. AU - Noordman, B. J. PY - 2014 DA - 2014// TI - Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study JO - Arthritis Rheumatol VL - 66 UR - https://doi.org/10.1002/art.38296 DO - 10.1002/art.38296 ID - Vastert2014 ER - TY - STD TI - Sikora KA, Grom AA. Update on the pathogenesis and treatment of systemic idiopathic arthritis. Curr Opin Pediatr 2011; 23(6): 640–646. doi: https://doi.org/10.1097/MOP.0b013e32834cba24. Review. ID - ref35 ER - TY - JOUR AU - Frampton, J. E. PY - 2013 DA - 2013// TI - Tocilizumab: a review of its use in the treatment of juvenile idiopathic arthritis JO - Paediatr Drugs VL - 15 UR - https://doi.org/10.1007/s40272-013-0053-1 DO - 10.1007/s40272-013-0053-1 ID - Frampton2013 ER - TY - JOUR AU - Horneff, G. PY - 2015 DA - 2015// TI - Safety of biologic therapies for the treatment of juvenile idiopathic arthritis JO - Expert Opin Drug Saf VL - 14 UR - https://doi.org/10.1517/14740338.2015.1042453 DO - 10.1517/14740338.2015.1042453 ID - Horneff2015 ER - TY - JOUR AU - Kessler, E. A. AU - Vora, S. S. AU - Verbsky, J. W. PY - 2012 DA - 2012// TI - Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome JO - Pediatr Rheumatol Online J VL - 10 UR - https://doi.org/10.1186/1546-0096-10-30 DO - 10.1186/1546-0096-10-30 ID - Kessler2012 ER - TY - JOUR AU - Beutler, B. AU - Cerami, A. PY - 1986 DA - 1986// TI - Cahcectin tumor necrosis factor: an endgenous mediator of shock and inflammation JO - Immunol VL - 5 ID - Beutler1986 ER - TY - JOUR AU - Jain, J. AU - Gautam, V. AU - Naseem, S. PY - 2011 DA - 2011// TI - Acute-phase proteins: as diagnostic tool JO - J Pharm Bioallied Sci VL - 3 UR - https://doi.org/10.4103/0975-7406.76489 DO - 10.4103/0975-7406.76489 ID - Jain2011 ER - TY - JOUR AU - Opstelten, W. AU - Bijlsma, J. W. AU - Gelinck, L. B. AU - Hielkema, C. M. AU - Verheij, T. J. AU - van Eden, W. PY - 2016 DA - 2016// TI - Impaired immunity: risk groups and consequences for general practice JO - Ned Tijdschr Geneeskd VL - 160 ID - Opstelten2016 ER - TY - JOUR AU - Shimizu, M. AU - Nakagishi, Y. AU - Kasai, K. PY - 2012 DA - 2012// TI - Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6 JO - Cytokine VL - 58 UR - https://doi.org/10.1016/j.cyto.2012.02.006 DO - 10.1016/j.cyto.2012.02.006 ID - Shimizu2012 ER - TY - JOUR AU - Wittkowski, H. AU - Frosch, M. AU - Wulffraat, N. PY - 2008 DA - 2008// TI - S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.24137 DO - 10.1002/art.24137 ID - Wittkowski2008 ER - TY - JOUR AU - Frosch, M. AU - Holzinger, D. AU - Roth, J. PY - 2012 DA - 2012// TI - Systemic onset juvenile idiopathic arthritis JO - Monatschr Kinderheilkd VL - 160 UR - https://doi.org/10.1007/s00112-011-2545-9 DO - 10.1007/s00112-011-2545-9 ID - Frosch2012 ER -