Skip to main content

Table 1 Characteristics of all vaccinated patients

From: The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey

Pt

Gender

Age (y)

Country

Disease

Disease activity

Biological

Other DMARDs

Vaccination

Adverse events

Flare

1

Female

7

USA

sJIA

Inactive

Anakinra 4 mg/kg/day

Prednisone (0.12 mg/kg/day) Methotrexate Leflunomide Thalidomide

Varicella zoster (booster)

Varicella zoster infection

2

Female

1

Turkey

sJIA

Inactive

Canakinumab 4 mg/kg/2 months

Prednisone (5 mg/day) Methotrexate

MMR booster

Pneumonia

Yes

3

Male

2

Turkey

sJIA

Inactive

Tocilizumab 12 mg/kg/monthly

Prednisone (2.5 mg/day)

Oral polio vaccine

Diarrhea

4

Male

12

USA

MKD

Inactive

Anakinraa 100 mg/day (STOP 3-4D-1D)

Varicella zoster (booster)

Yes

5

Male

9

USA

MKD

Inactive

Anakinraa 150 mg during flare (STOP 2D-1D)

Varicella zoster (booster)

Yes

6

Female

4

USA

MKD

Partially active

Canakinumaba 4 mg/kg/6 weeks (STOP 3 M–3 M)

 

Varicella zoster (first vaccine) and MMR first vaccine

Yes

7

Female

2

Turkey

FMF

Inactive

Canakinumab 4 mg/kg/monthly

Prednisone (2.5 mg/day) Colchicine

MMR booster

Yes

8

Female

9

Netherlands

sJIA

Inactive

Anakinraa 1.7 mg/kg/2 days (STOP 2D-3D)

Methotrexate

MMR booster

Yes

9

Male

3

Netherlands

sJIA

Inactive

Tocilizumab 132 mg/14 days)

Prednisone (2.5 mg/day)

Varicella zoster (first vaccine)

Yes

10

Male

12

Italy

CAPS

Inactive

Anakinraa 1.5 mg/kg/day (STOP 3D-14D)

Methylprednisolone (0.06 mg/kg/day)

MMR booster

11

Female

12

Italy

MKD

Partially active

Anakinraa 1.4 mg/kg/day (STOP 3D-28D)

MMR booster

12

Female

9

Netherlands

sJIA

Inactive

Anakinra 40 mg/3 days

MMR booster

13

Male

9

Netherlands

sJIA

Inactive

Tocilizumab 8 mg/kg/2 weeks

Methotrexate

MMR booster

14

Female

58

United Kingdom

CAPS

Inactive

Anakinraa 100 mg/day (STOP 3D-3D)

Yellow fever (first vaccine)

15

Female

28

United Kingdom

CAPS

Inactive

Anakinraa 100 mg/day (STOP 3D-3D)

Yellow fever (first vaccine)

16

Female

26

United Kingdom

CAPS

Inactive

Anakinraa 100 mg/day (STOP 3D-3D)

Yellow fever (first vaccine)

17

Female

44

United Kingdom

CAPS

Inactive

Canakinumab (150 mg/2 months)

Yellow fever (first vaccine)

  1. aBiological stopped prior to vaccination and restarted after vaccination. The period of discontinuation before and after vaccination is indicated in brackets.
  2. D days before or after vaccination, M months before or after vaccination