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Table 2 Demographic characteristics and baseline immunological data for participants

From: Varicella-zoster-virus vaccination in immunosuppressed children with rheumatic diseases using a pre-vaccination check list

Characteristic Overall Low-intensity immunosuppression (LIIS) High-intensity immunosuppression (HIIS) p value
Number 23 9 (39%) 14 (61%)  
Female 17 (74%) 8 (89%) 10 (71%) 0.32a
Age, median (range) years 9.6 (1.8-17.8) 8.3 (1.8-17.8) 9.7 (2.7-17.8) 0.33b
Disease type   8 JIA 11 JIA  
6 oligoarthritis 3 oligoarthritis
1 polyarthritis 3 polyarthritis
1 psoriatic arthritis 4 systemic arthritis
1 Sjögren syndrome 1 psoriatic arthritis
2 JDM
1 MPA
Immunosuppressive drug therapy   9 MTX <15mg/m2/wk 2 MTX ≥15mg/m2/wk N/A
1 MTX+TCZ
1 MTX+ADA
1 MTX+ANK+PDN
1 LEF
1 LEF+ABA
1 LEF+ANK+PDN
1 LEF+ETN+PDN
1 LEF+TCZ
2 ETN
1 ETN+PDN
1 MMF
Varicella vaccine history     0.31a
0 previous doses 15 7 8
1 previous dose 8 2 6
Baseline white blood cell count, median (range) per mm3 5900 (4100-8311) 5100 (4100-6900) 6715 (4400-8311) 0.12b
Baseline absolute lymphocyte count, median (range) per mm3 2433 (1156-4647) 2295 (1156-3200) 2519 (1158-4647) 0.63b
Serum IgG, mean (SD) mg/dl 793 (542-1803) 793 (637-1803) 787 (542-1403) 0.61b
Tetanus toxoid antibody, mean (SD) IU/ml 1.4 (0.1-6.2) 2.2 (0.16-6.2) 0.6 (0.1-2.7) 0.01b
CD4+ T cell count, mean (SD) per mm3 N/A N/A 1371 (546) N/A
Positive T cell function, n (%) N/A N/A 14 (100) N/A
  1. Abbreviations: ABA abatacept, ADA adalimumab, ANK anakinra, JIA juvenile idiopathic arthritis, JDM juvenile dermatomyositis, ETN etanercept, LEF leflunomide, MMF mycophenolate mofetil, MPA microscopic polyangiitis, MTX methotrexate, N/A not applicable, PDN prednisolone, SD standard deviation, TCZ tocilizumab, WBC white blood cells.
  2. achi-square test; bMann Whitney test