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Table 1 Demographic and baseline characteristics of patients with suspected adult-onset Still’s disease (AOSD)

From: Application of the international league against rheumatism classification criteria for systemic juvenile idiopathic arthritis as a prognostic factor in patients with adults-onset Still’s disease

Characteristics AOSD suspected,
but not diagnosed(N = 37)
AOSD patients(N = 132) P-value
Age (year) 39.4 ± 12.8 41.9 ± 15.9 0.37
Sex (Male) 15 (41%) 38 (29%) 0.17
Fever 29 (78%) 130 (98%) <.001
Sore throat 11 (30%) 71 (54%) 0.010
Maculopopular skin rash 12 (32%) 102 (77%) <.001
Lymphadenopathy 5 (14%) 45 (34%) 0.015
Splenomegaly 4 (11%) 29 (22%) 0.130
Hepatomegaly 2 (5%) 17 (13%) 0.200
Pericarditis 0 (0%) 11 (8%) 0.069
Pleuritis 0 (0%) 11 (8%) 0.069
Arthralgia 28 (76%) 117 (89%) 0.046
Arthritis 9 (24%) 64 (48%) 0.009
Hemoglobin, g/dL 12.5 ± 0.2 11.4 ± 0.1 <.001
Leukocytes, /μL 7295.1 ± 523.5 14,708.8 ± 599.3 <.001
Neutrophils, /μL 4714.7 ± 451.3 12,734.8 ± 594.8 <.001
lymphocyte, /μL 1838.0 ± 154.6 1100.9 ± 48.0 <.001
Platelets, ×  103 μL 274.0 ± 16.2 301.1 ± 11.8 0.26
ESR, mm/h 40.4 ± 5.2 64.8 ± 2.6 <.001
CRP, mg/dL 4.3 ± 1.1 11.6 ± 0.7 <.001
AST, mg/dL 56.5 ± 17.4 93.3 ± 17.4 0.065
ALT, mg/dL 66.7 ± 21.7 94.2 ± 21.7 0.28
Ferritin, mg/dL 721.4 ± 246.0 6007.6 ± 887.3 0.002
LDH, mg/dL 334.0 ± 52.8 593.5 ± 103.0 0.21
ANA positivity 8 (29%) 21 (17%) 0.16
RF positivity 3 (9%) 10 (8%) 0.85
Systemic score 2.6 ± 0.2 5.0 ± 0.1 <.0001
  1. AOSD adult-onset Still’s disease, ESR erythrocyte sedimentation rate, CRP C-reactive protein, AST aspartate transaminase, ALT alanine transaminase, LDH lactate dehydrogenase, ANA antinuclear antibody, RF rheumatoid factor. All values are presented as the number (%) or the mean ± SE except the age as the mean ± SD. Systemic scores (0–12) were obtained using the method described by Pouchot et al. [7], with 1 point assigned for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function tests, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain