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Table 1 Demographic and baseline characteristics of patients with suspected adult-onset Still’s disease (AOSD)

From: Application of the international league against rheumatism classification criteria for systemic juvenile idiopathic arthritis as a prognostic factor in patients with adults-onset Still’s disease

Characteristics

AOSD suspected,

but not diagnosed(N = 37)

AOSD patients(N = 132)

P-value

Age (year)

39.4 ± 12.8

41.9 ± 15.9

0.37

Sex (Male)

15 (41%)

38 (29%)

0.17

Fever

29 (78%)

130 (98%)

<.001

Sore throat

11 (30%)

71 (54%)

0.010

Maculopopular skin rash

12 (32%)

102 (77%)

<.001

Lymphadenopathy

5 (14%)

45 (34%)

0.015

Splenomegaly

4 (11%)

29 (22%)

0.130

Hepatomegaly

2 (5%)

17 (13%)

0.200

Pericarditis

0 (0%)

11 (8%)

0.069

Pleuritis

0 (0%)

11 (8%)

0.069

Arthralgia

28 (76%)

117 (89%)

0.046

Arthritis

9 (24%)

64 (48%)

0.009

Hemoglobin, g/dL

12.5 ± 0.2

11.4 ± 0.1

<.001

Leukocytes, /μL

7295.1 ± 523.5

14,708.8 ± 599.3

<.001

Neutrophils, /μL

4714.7 ± 451.3

12,734.8 ± 594.8

<.001

lymphocyte, /μL

1838.0 ± 154.6

1100.9 ± 48.0

<.001

Platelets, ×  103 μL

274.0 ± 16.2

301.1 ± 11.8

0.26

ESR, mm/h

40.4 ± 5.2

64.8 ± 2.6

<.001

CRP, mg/dL

4.3 ± 1.1

11.6 ± 0.7

<.001

AST, mg/dL

56.5 ± 17.4

93.3 ± 17.4

0.065

ALT, mg/dL

66.7 ± 21.7

94.2 ± 21.7

0.28

Ferritin, mg/dL

721.4 ± 246.0

6007.6 ± 887.3

0.002

LDH, mg/dL

334.0 ± 52.8

593.5 ± 103.0

0.21

ANA positivity

8 (29%)

21 (17%)

0.16

RF positivity

3 (9%)

10 (8%)

0.85

Systemic score

2.6 ± 0.2

5.0 ± 0.1

<.0001

  1. AOSD adult-onset Still’s disease, ESR erythrocyte sedimentation rate, CRP C-reactive protein, AST aspartate transaminase, ALT alanine transaminase, LDH lactate dehydrogenase, ANA antinuclear antibody, RF rheumatoid factor. All values are presented as the number (%) or the mean ± SE except the age as the mean ± SD. Systemic scores (0–12) were obtained using the method described by Pouchot et al. [7], with 1 point assigned for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function tests, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain