Table 1 Clinical characteristics of CNO compared with other bone diseases
From: Dealing with Chronic Non-Bacterial Osteomyelitis: a practical approach
CNO | Bacterial Osteomyelitis | Malignancy | Osteoid Osteoma | DIRA | PAPA | Cherubism | Osteopetrosis | |
|---|---|---|---|---|---|---|---|---|
Multifocal Involvement | +++ | – | + | – | + | −/+ | + | +++ |
Pain | ++++ | ++++ | ++++ | ++++ | ++ | +++ | ++ | ++ |
Fever | + | +++ | −/+ | – | −/+ | −/+ | – | – |
Skin Involvement | + | – | – | – | ++++ | +++ | – | – |
Articular Involvement | + | ++ | – | – | ++++ | ++++ | – | – |
Bone Swelling | +++ | −/+ | ++ | – | ++ | ++ | ++++ | ++ |
Renal Involvement | + | – | −/+ | – | – | + | – | – |
Hepatosplenomegaly | – | – | + | – | ++++ | – | – | ++ |
Early Age of onset | −/+ | + | −/+ | – | ++++ | – | – | ++ |
ESR/CRP elevation | + | +++ | −/+ | – | ++++ | ++++ | – | – |
Leukocytosis | −/+ | +++ | −/+ | – | ++++ | ++++ | – | – |