A national cohort study on pediatric Behçet’s disease: cross-sectional data from an Italian registry

Table 1 Comparison of clinical features of BD in different geographical regions

	present study	Davatchi 2010 Iran [20]	Atmaca 2011 Turkey [18]	Karincaoglu 2008 Turkey [21]	Konet-Paut 1998 International study [17]	Sungur 2009 Turkey [14]	Hamzaoui 2014 Tunisia [13]	Kim 1994 Korea [19]	Brogan 2016 UK [12]
Total number of PEDBD patients	110	1973	110	83	86	62	81	40	46
Male/female ratio	1.3	1.0	0.6	0.8	1.0	1.1	2.1:1	0.67	0.9
Average age at onset	8.3	n.r.	11.6 ± 3.4	12.3	8.4	n.r.	16.12 ± 3.7	n.r.	4.87
ROA	94.5^a	97.8	100	100	97.2	100	100	100	97.8
GU	33.6	64.7	82.7	82	60.4	55	76.5	82.5	74
Skin manifestations	39.6	65.3	76	n.r.	93	n.r.	88.9	72.5	32.6
Ocular involvement	43.6	56.1	30.9	35	57	n.r.	44.4	27.5	8.7
Vascular manifestations	1.8	6.5	3.6	9.6	16.2	5	32.1	n.r.	6.5
Joint involvement	42.7	37.1	22.7	40	45.3	42	40.7	27.5	52
CNS	30.9	10.3	3.6	7.2	36	13	22.2	2.5	32.6
GI lesions	42.7	7.6	n.r.	4.8	14	n.r.	n.r.	5	58.7
Pathergy phenomenon	14.5¹	49.4	45.5	37	63.2²	47	55.7	17.5	60³
Relatives affected	12⁴	n.r.	12.3	19	16.2	42	n.r.	22.5	17

ROA Recurrent oral aphtosis, GU Genital ulcers, CNS central nervous system, GI Gastrointestinal, nr not reported
^aall clinical manifestations are expressed in percentage
¹Pathergy test was performed in 103/110 patients and was positive in 15/103
²Pathergy test was performed in 68/86 patients and was positive in 43/86
³Pathergy test was performed in 5 patients and was positive in 3/5
⁴Data not known in 10 patients; 12/110 patients had a positive family history

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