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Table 2 Influenza A/(H1N1)pdm, A/H3N2 and B virus antibody response in JIA patients receiving or not biological therapy

From: Immunogenicity and safety of influenza vaccination in patients with juvenile idiopathic arthritis on biological therapy using the microneutralization assay

  Control group
(n = 6)
JIA group
(n = 35)
p-value Biological therapy
(n = 25)
No biological therapy
(n = 10)
p-value
A/H1N1
GMT
 Pre-vaccine (range) 31.7 (10 -160) 47.8 (5-1280) 0.388 45.9 (5 -320) 52.7 (5 -1280) 0.504
 Post-vaccine (range) 320 (160-1280) 273.1 (20-2560) 0.684 242.5 (20-2560) 367.5 (40-2560) 0.535
GMR mean (range) 6.10 (2.7-22.3) 5.1 (2.7-85.2) 0.646 4.89 (2.71-85.2) 5.99 (2.71-30.2) 0.510
Seroprotection
 Pre-vaccine- n (%) 3 (50) 24 (68.6) 0.375 18 (72.0) 6 (60) 0.490
 Post-vaccine- n (%) 6 (100) 34 (97.1) 0.675 24 (96) 10 (100) 0.521
Seroconversion- n(%) 5 (83.3) 23 (65.7) 0.391 15 (60) 8 (80) 0.260
A/H3N2
GMT
 Pre-vaccine (range) 22.44 (5-80) 38.44 (5-2560) 0.562 34.82 (5-80) 49.2 (5-2560) 0.334
 Post-vaccine (range) 320 (80-2560) 233.0 (20-2560) 0.684 199.7 (20-2560) 342.9 (80-2560) 0.565
GMR mean (range) 8.0 (3.1-35.0) 4.9 (2.7-22.3) 0.079 4.70 (2.7-13.7) 5.66 (2.7-22.4) 0.383
Seroprotection
 Pre-vaccine- n (%) 3 (50) 22 (62.9) 0.551 17 (68.0) 5 (50.0) 0.319
 Post-vaccine- n(%) 6 (100) 34 (97.1) 0.675 24 (96) 10 (100) 0.521
Seroconversion- n(%) 5 (83.3) 22 (62.9) 0.328 15 (60) 7 (70) 0.580
Flu B
GMT
 Pre-vaccine (range) 63.4 (40-80) 40.8 (5-640) 0.114 26.1 (5-640) 37.3 (5-320) 0.912
 Post-vaccine (range) 640 (40-2560) 118.9 (20-1280) 0.396 91.9 (20-1280) 226.2 (20-1280) 0.871
GMR mean (range) 4.7 (2.7-8.3) 3.8 (2.7-9.8) 0.235 3.6 (2.7-9.9) 4.7 (3.06-6.70) 0.038
Seroprotection
 Pre-vaccine n (%) 6 (100) 24 (68.6) 0.108 17 (68.0) 7 (70) 0.908
 Post-vaccine n (%) 6 (100) 31 (88.6) 0.383 22 (88.0) 9 (90.0) 0.867
Seroconversion n (%) 4 (66.7) 17 (48.6) 0.413 9 (36) 8 (80) 0.019
  1. Parameters were compared by multiple comparison chi-square test or linear regression. GMR geometric mean ratio, GMT geometric mean titer