From: Proceedings of the 24th Paediatric Rheumatology European Society Congress: Part one
Clinical Outcomes Mean (95% CI) | Safety Summary (to m72) N (EP100PY) unless otherwise stated | ||||||||
---|---|---|---|---|---|---|---|---|---|
 | BL1(n = 127) | m241(n = 109) | m482(n = 64) | m722(n = 47) |  | eoJIAEXP = 245.607 PY | ERAEXP = 158.888 PY | PsAEXP = 119.945 PY | TotalEXP = 524.441 PY |
PtGA | 4.96 (4.6,5.4) | 0.97 (0.7,1.2) | 1.32 (0.9,1.8) | 1.29 (0.9,1.7) | TEAEs* | 244 (99.35) | 151 (95.04) | 90 (75.03) | 485 (92.48) |
PGA | 5.02 (4.7,5.3) | n = 108 0.62 (0.5,0.8) | n = 63 0.67 (0.5,0.9) | 0.76 (0.5,1.0) | TE infections | 351 (142.91) | 93 (58.53) | 117 (97.54) | 561 (106.97) |
CRP, mg/L | 8.26 (5.7,10.8) | n = 103 2.76 (1.7,3.8) | 2.85 (1.6,4.1) | n = 46 1.58 (1.2,2.0) | TEAEs* causing withdrawal, n (%) | 5 (2.04) | 8 (5.03) | 0 | 13 (2.48) |
JADAS 73 joints | n = 119 17.16 (15.9,18.4) | n = 102 2.28 (1.7,2.9) | n = 61 2.48 (1.8,3.1) | n = 29 3.12 (2.2,4.1) | TE infections causing withdrawal, n (%) | 2 (0.81) | 0 | 1 (0.83) | 3 (0.57) |
No. active joints | 6.74 (5.9,7.6) | 0.61 (0.2,1.0) | n = 63 0.49 (0.3,0.7) | n = 30 0.60 (0.2,1.0) | Serious TEAEs | 11 (4.48) | 17 (10.70) | 4 (3.33) | 32 (6.10) |
No. active joints (LOM) | 5.72 (5.0,6.5) | 1.06 (0.5,1.6) | n = 63 1.02 (0.6,1.4) | n = 30 1.10 (0.5,1.8) | Serious TE infections | 5 (2.04) | 4 (2.52) | 4 (3.33) | 13 (2.48) |
Opportunistic infections†| 0 | 1 (0.63) | 1 (0.83) | 2 (0.38) |