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Table 1 Clinical, laboratory, and demographic features of patients with chronic nonbacterial osteomyelitis

From: Bone metabolism and inflammatory characteristics in 14 cases of chronic nonbacterial osteomyelitis

 

Chief compliment

Sex

Age (years)

The time between first symptom and diagnosis(months)

Follow-up (months)

CRP (mg/dL)

ESR (mm/h)

SAA (μg/mL)

IgG (mg/dL)

BAP (μg/L)

TRAP5b (mU/dL)

Number of bones with high accumulation on FDG-PET

Bone lesions with high signal on T2-STIR MRI

BMD(g/cm2)

Z score

Treatment

Treatment response to first line therapy

1

Fever of unknown origin

F

13

18

46

0.09

33

27

1722

37.4

338

8

33

0.921

−0.8

N + B

no response

2

Pain in the left hand

M

15

3

44

0.01

5

<5

1620

42.3

1870

8

24

0.726

−3.7

N

no response

3

Pain in the right foot

M

12

12

45

0.49

35

56

1524

82.8

1170

1

29

N/A

N/A

N

no response

4

Pain in both femurs

M

12

4

56

2.56

59

143

1561

53.5

1050

8

8

0.582

−2.1

N + B

no response

5

Pain in both hands

F

11

9

26

0.01

2

<5

802

30.2

239

2

10

0.667

−2.2

N + B

clinical remission

6

Pain in the right foot

M

12

5

48

0.01

1

<5

1057

62.8

1620

3

3

0.742

−1.5

N + B

clinical remission

7

Fever of unknown origin

F

15

3

52

0.4

18

26

1361

8.1

270

11

27

0.999

−0.3

N + B

partial response

8

Pain in both knees

F

5

2

33

0.02

7

<5

993

65.5

914

4

8

N/A

N/A

N + B

clinical remission

9

Fever of unknown origin and pain in the left knee

M

10

24

22

0.54

77

58

1561

49.49

2150

2

2

0.601

−1.4

N

partial response

10

Pain in both feet and knees

M

13

13

31

0.04

5

<5

1255

116.4

2430

4

4

0.688

−2.1

N + B

partial response

11

Pain in both feet

F

10

11

31

0.01

4

<5

1255

62.2

843

4

4

0.593

−2.8

N + B

clinical remission

12

Pain in both feet

M

12

4

32

0.19

16

14

1150

94.2

1500

5

2

0.505

−2.9

N + B

partial response

13

Pain in the right foot

M

8

5

29

0.01

2

6

1293

64.1

717

1

3

0.554

−1.9

N + B

partial response

14

Pain in both feet and knees

M

10

3

22

3.49

51

50

879

72

1320

6

8

0.513

−2.6

N + B

partial response

Mean

 

Girls: 5 Boys: 9

11.3

8.3

37

0.6

23

48

1288

60

1174

4.8

11.8

0.7

−2.0

NSAIDs alone: 3 NSAIDs + Bisphosphonate: 11

Clinical remission: 4 Partial response: 6 No response: 4

  1. Abbreviations: F female, M male, CRP C-reactive protein, ESR erythrocyte sedimentation rate, SAA serum amyloid A, IgG immunoglobulin G, BAP bone alkaline phosphatase, TRAP5b tartrate-resistant acid phosphatase serum band 5bm, BMD bone mineral density, NNSAIDs, B Bisphosphonate