Table 1 Published prevalence rates of GI adverse effects associated with MTX in the treatment of JIA
From: Methotrexate-induced nausea in the treatment of juvenile idiopathic arthritis
Author | Year published | Study design | Number of subjects | Method of ascertainment | MTX-intolerance due to GI effects | Nausea with MTX | Vomiting with MTX | Anticipatory nausea |
|---|---|---|---|---|---|---|---|---|
Bulatovic | 2011 | Cross-sectional | 297 patients | MISS | 51% | 64% | 27% | 9% |
van Dijkhuizen | 2015 | Cohort study of new MTX initiators | 142 patients | MISS | 42% (1Â year incidence) | (n/a) | (n/a) | (n/a) |
Ruperto | 2004 | Randomized clinical trial of MTX | 80 patients | Direct questioning | (n/a) | 21% (monthly) | 11% (monthly) | (n/a) |
Patil | 2014 | Survey | 49 patients | Questionnaire | (n/a) | 73% | 43% | 41% |
Woo | 2000 | Randomized clinical trial of MTX | 88 patients | Direct questioning | (n/a) | 28% (monthly) | (n/a) | (n/a) |
Mulligan | 2013 | Survey | 171 parents | Questionnaire | (n/a) | ~32% (weekly) | 15% (weekly) | 25% (weekly) >35% (any) |
Amin | 2015 | Survey | 84 physicians | Questionnaire | (n/a) | ~25% in first year | (n/a) | |