Skip to main content

Table 1 Crohn’s disease and Behçet’s disease: clinical features

From: Intestinal Behçet and Crohn’s disease: two sides of the same coin

  Crohn’s disease Behcet’s disease
Clinical manifestations Abdominal pain, diarrhoea, rectal bleeding, nausea, vomiting, weight loss and fever Oral and genital ulcers, joints and neurological involvement
Extra intestinal manifestations Uveitis, arthritis, pyoderma gangrenosum, erythema nodosum, iron deficiency anaemia Uveitis, arthritis, pyoderma gangrenosum, erythema nodosum, vaso-occlusive disease and thrombotic events
Histological features Discontinuous distribution of longitudinal ulcers, aphthous and cobblestone appearance, focal cryptitis and epithelioid granulomas Mucosal inflammation and ulceration; signs of vasculitis.
Most involved gender Female Male
Genetic predominant factor NOD2/CARD15 (16p12-q13), CXCL16 (17p13), STAT6 (12q13), TLR4 (9q33), CARD9 (9q34.3) HLA-B51
Therapy Systemic corticosteroids 5-ASA/sulfasalazine Thiopurines or AZA/6-MP Anti TNF-α agents Nutritional therapy Colchicine Systemic corticosteroids Mycophenolate mofetil Cyclophosphamide Thiopurines or AZA/6-MP Anti TNF-α agents
Surgery Patients refractory to medical treatment or with complications Refractory to medical treatment or with complications such as perforations, fistulae formation, and massive gastrointestinal bleeding