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Table 3 Associated Risk Factors for the presence of BK Viruria and/or Viremia in children with SLE at the time of enrollment

From: BK viruria and viremia in children with systemic lupus erythematosus

Clinical history

Presence of Bk viruria or viremia (N = 12)

Absence of BK viruria or viremia (N = 20)

P-value

 

Median

Median

 

Age

15

16

0.08

Female

9

17

0.65

Male

3

3

Race

  

0.79

Caucasian

4

8

African American

3

6

Other

5

6

SLE WHO Class

  

0.75

I

2

2

II

1

1

III

0

1

III/IV

1

0

IV

3

8

V

2

2

No renal biopsy

3

6

Duration of SLE

21

21

0.89

Laboratory findings

Serum creatinine

0.61

0.66

0.33

Hematuria

1

2

1.0

Proteinuria

2

4

1.0

Hemoglobin

12.45

12.25

0.56

Platelet count

269.5

243

0.77

WBC Count

5.05

5.95

0.89

C3

106

113

0.77

C4

18

19

0.88

CD3

982

1087

0.44

CD19

0

0

0.23

IGG

796

866

0.80

IGA

86

143

0.21

IGM

30

29

0.88

Medication history

   

Exposure to any biologic a

11

16

0.62

1 Biologic

10

13

2 Biologics

0

2

3 OR more biologics

1

1

Exposure to IVIG

5

6

0.70

Exposure to hydroxychloroquine

12

9

0.0016 b

Exposure to MMF

9

17

0.65

Exposure to cyclophosphamide

3

11

0.15

Exposure to rituximab

10

15

0.68

Exposure to steroids

12

20

1.0

  1. N number of patients
  2. a Two biologics (Rituximab and Tocilizumab) were given simultaneously in only one patient (patient # 5)
  3. b Statistically significant p-value