From: BK viruria and viremia in children with systemic lupus erythematosus
Clinical history | Presence of Bk viruria or viremia (N = 12) | Absence of BK viruria or viremia (N = 20) | P-value |
---|---|---|---|
Median | Median | ||
Age | 15 | 16 | 0.08 |
Female | 9 | 17 | 0.65 |
Male | 3 | 3 | |
Race | 0.79 | ||
Caucasian | 4 | 8 | |
African American | 3 | 6 | |
Other | 5 | 6 | |
SLE WHO Class | 0.75 | ||
I | 2 | 2 | |
II | 1 | 1 | |
III | 0 | 1 | |
III/IV | 1 | 0 | |
IV | 3 | 8 | |
V | 2 | 2 | |
No renal biopsy | 3 | 6 | |
Duration of SLE | 21 | 21 | 0.89 |
Laboratory findings | |||
Serum creatinine | 0.61 | 0.66 | 0.33 |
Hematuria | 1 | 2 | 1.0 |
Proteinuria | 2 | 4 | 1.0 |
Hemoglobin | 12.45 | 12.25 | 0.56 |
Platelet count | 269.5 | 243 | 0.77 |
WBC Count | 5.05 | 5.95 | 0.89 |
C3 | 106 | 113 | 0.77 |
C4 | 18 | 19 | 0.88 |
CD3 | 982 | 1087 | 0.44 |
CD19 | 0 | 0 | 0.23 |
IGG | 796 | 866 | 0.80 |
IGA | 86 | 143 | 0.21 |
IGM | 30 | 29 | 0.88 |
Medication history | |||
Exposure to any biologic a | 11 | 16 | 0.62 |
1 Biologic | 10 | 13 | |
2 Biologics | 0 | 2 | |
3 OR more biologics | 1 | 1 | |
Exposure to IVIG | 5 | 6 | 0.70 |
Exposure to hydroxychloroquine | 12 | 9 | 0.0016 b |
Exposure to MMF | 9 | 17 | 0.65 |
Exposure to cyclophosphamide | 3 | 11 | 0.15 |
Exposure to rituximab | 10 | 15 | 0.68 |
Exposure to steroids | 12 | 20 | 1.0 |