Fig. 1

Evolution of symptoms according to age of life (in months). 5 months: Initial symptoms were erythematous skin lesions distributed over the whole body (a–c). 8 months: Macrohaematuria, epistaxis and bloody diarrhoea were reported. 9 months: Fever episodes every second week. 12 months: Deep skin lesions with excoriation and ulcerations (d). Anisocoria (g) and unilateral facial swelling with sudden occurrence and transient (h). 16 months: deep ulcerating or necrotizing skin lesions with impaired heeling at bone marrow puncture site (e) or vaccination sites (f). 18 months: bullous skin lesions occurred with sudden detachment of epidermal layers with predominantly palmar and plantar localisation (i). Blisters healed without scarring usually after 2 weeks (j)