Table 2 Frequency and main features of lung involvement in patients affected with GPA in pediatric series
From: Lung involvement in childhood onset granulomatosis with polyangiitis
First author and year of publication | Number of patients | Median age at diagnosis (range) | Female | Lung involvement (%) | Hemopstysis/Alveolar haemorrage | Dyspnea | Chronic cough | Pleural effusion/thickening | Lung nodules or cavity | Lung infiltrate |
|---|---|---|---|---|---|---|---|---|---|---|
Tahghighi 2013 [23] | 11 | 11 (6–15) | 5 | 7 (63,6%) | 2 | 2 | N.R. | 1 | N.R. | N.R. |
Iudici 2015 [25] | 25 | 14 (2–17) | 18 | 17 (68%) | 3 | 3 | N.R. | N.R. | 7 | 6 |
Sacri 2015 [26] | 28 | 12,8 (10,1–14,6) | 21 | 19 (67,8%) | 12 | N.R. | N.R. | 1 | 7 | 16 |
Bohm 2014 [30] | 56 | N.R. | 38 | 44 (78,5%) | 14/55 | N.R. | N.R. | 7 | 17 | 26/55 |
Kosalka 2014 [31] | 9 | N.R. | 6 | 8 (88,9%) | 4 | N.R. | N.R. | 2 | 4 | 2 |
Cabral 2016 [32] | 183 | 14 (2–18) | 113 | 136 (74,3%) | 76 | 15 | 99 | 25 | 97 | 64 |
Belostotsky 2002 [33] | 17 | N.R. | 13 | 14 (82,3%) | 3 | 4 | 9 | N.R. | 2 | 2 |
Akikusa 2007 [22] | 25 | 14,5 (8,7–17,1) | 20 | 21 (84%) | 12 | N.R. | N.R. | 2 | 13 | 6 |
Arulkumaran 2011 [27] | 7 | N.R. | 5 | 5 (71,4%) | 2 | N.R. | N.R. | N.R. | N.R. | N.R. |
Wong 1998 [28] | 12 | N.R. | 8 | 7 (58,3%) | 3 | N.R. | N.R. | N.R. | N.R. | N.R. |