Juvenile Idiopathic Arthritis | Inflammatory Bowel Disease | |
---|---|---|
Onset of the disease | Acute onset with high, quotidian fevers, | Typically subacute illness with fatigue, anemia, and weight loss. Occasionally more fulminant presentation. |
Gastrointestinal symptoms | Frequently abdominal pain, also nausea and anorexia | Loose stools and/or bloody diarrhea, abdominal pain, tenesmus |
Muskuloskeletal symptoms | Initially, mild oligoarticular arthritis, frequently severe polyarthritis over the course of the disease | Nonerosive, asymmetric arthritis, affecting the large joints, parallel to intestinal involvement |
Skin manifestations | Initial presentation with evanescent, salmon-colored, cutaneous eruption | Erythema nodosum, pyoderma gangrenosum |
Laboratory abnormalities | Anemia, reactive thrombocytosis, markedly elevated erythrocyte sedimentation rate and C-reactive protein. Significantly elevated ferritin. Typically negative antinuclear antibodies and rheumatoid factor. | Anemia, elevated erythrocyte sedimentation rate and C-reactive protein, depressed albumin level, occult blood in the stool, elevated fecal calprotectin. Ferritin typically low or normal. Typically negative antinuclear antibodies and rheumatoid factor. |