Table 2 Colonoscopy findings, clinical and laboratory data at time of diagnosis of IBD of the patients
Patient | 1 | 2 | 3 |
|---|---|---|---|
Time between diagnoses of sJIA and IBD | 0.9 years | 4.4 years | 4.7 years |
Time between start of Anti-IL1 agent and IBD | 0.9 years | 2.2 years | 4.4 years |
Anti-IL1 agents, dosage | Anakinra, 1.3 mg/kg | Canakinumab, 1.8 mg/kg | Anakinra, 0.7 mg/kg |
Other medications | None | Cyclosporin A | None |
Colonoscopy, macroscopic findings | Active, ulcerous ileitis and colitis, consistent with Crohn’s disease | Active colitis from sigmoid to coecum, consistent with Crohn’s disease | Colitis in colon descendens, consistent with ulcerative colitis |
Colonoscopy, microscopic findings | Granulomatous inflammation | Inflammatory infiltrate | Inflammatory infiltrate |
Diarrhea | Present | Present | Present |
Macroscopic blood in stool | Absent | Absent | Present |
Ferritin | 138 ng/ml (9–80) | 154 ng/ml (30–400) | 10 ng/ml (30–400) |
CRP | 12.1 mg/dl (< 0.8) | 4.67 mg/dl (0.02–1.0) | 0.44 mg/dl (0.2–1.0) |
Calprotectin/stool | Not available | 877 μg/g (<50) | 1264 μg/g (<50) |