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Table 3 HLA-G genotype, allele and haplotype frequencies in patients and healthy siblings

From: “HLA-G 3′UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population”

  Pooled Male Female
Patients (99) n (%) Healthysiblings (126) n (%) OR (95% CI) pc Patients (52) n (%) Healthy siblings (75) n (%) OR (95% CI) pc Patients (47) n (%) Healthy siblings (51) n (%) OR (95% CI) pc
14 bp Ins/Del
Genotypes
Ins/Ins 16 (16.2) 27 (21.4) 0.71 (0.36-1.40) 0.4084 9 (17.3) 24 (32.0) 0.44 (0.18-1.04) 0.0987 7 (14.9) 3 (5.9) 2.86 (0.69-11.77) 0.2418
Del/Del 35 (35.3) 36 (28.6) 1.37 (0.78-2.40) 0.3128 18 (34.6) 19 (25.3) 1.53 (0.71-3.32) 0.3755 17 (36.2) 17 (33.3) 1.17 (0.51-2.68) 0.8791
Ins/Del 48 (48.5) 63 (50.0) 0.94 (0.55-1.59) 0.9272 25 (48.1) 32 (42.7) 1.24 (0.61-2.53) 0.6734 23 (48.9) 31 (60.8) 0.62 (0.28-1.38) 0.3296
Alleles
Ins 80 (40.4) 117 (46.4) 0.78 (0.54-1.14) 0.2368 43 (41.3) 80 (53.3) 0.62 (0.37-1.02) 0.0797 37 (39.4) 37 (36.3) 1.14 (0.64-2.03) 0.7657
Del 118 (59.6) 135 (53.6) 1.28 (0.88-1.86) 0.2368 61 (58.7) 70 (46.7) 1.62 (0.98-2.70) 0.0797 57 (60.6) 65 (63.7) 0.88 (0.49-1.56) 0.7657
+3142 C/G
Genotypes
C/C 12 (12.1) 6 (4.8) 2.76 (0.99-7.63) 0.0763a 7 (13.5) 3 (4.0) 3.68 (0.90-14.98) 0.1121 5 (10.6) 3 (5.9) 1.94 (0.44-8.62) 0.6041
G/G 48 (48.5) 66 (52.4) 0.86 (0.50-1.45) 0.6556 27 (51.9) 44 (58.7) 0.76 (0.37-1.55) 0.5680 21 (44.7) 22 (43.1) 1.06 (0.48-2.37) 0.9602
C/G 39 (39.4) 54 (42.8) 0.87 (0.51-1.48) 0.6985 18 (34.6) 28 (37.3) 0.87 (0.41-1.82) 0.8556 21 (44.7) 26 (51.0) 0.81 (0.37-1.78) 0.7431
Alleles
C 63 (31.8) 66 (26.2) 1.31 (0.87-1.98) 0.2280 32 (30.8) 34 (22.7) 1.52 (0.86-2.66) 0.1927 31 (33.0) 32 (31.4) 1.08 (0.59-1.96) 0.9302
G 135 (68.2) 186 (73.8) 0.76 (0.50-1.15) 0.2280 72 (69.2) 116 (77.3) 0.66 (0.37-1.16) 0.1927 63 (67.0) 70 (68.6) 0.93 (0.51-1.69) 0.9302
Haplotypes
Ins/G 80 (40.4) 117 (46.4) 0.78 (0.54-1.40) 0.2368 43 (41.3) 80 (53.3) 0.62 (0.37-1.02) 0.0797 37 (39.4) 37 (36.3) 1.14 (0.64-2.03) 0.7657
Del/G 55 (27.8) 69 (27.4) 1.02 (0.67-1.55) 0.9898 29 (27.9) 36 (24.0) 1.22 (0.69-2.16) 0.5813 26 (27.6) 33 (32.3) 0.80 (0.43-1.48) 0.5756
Del/C 63 (31.8) 66 (26.2) 1.31 (0.87-1.98) 0.2280 32 (30.8) 34 (22.7) 1.49 (0.85-2.62) 0.2148 31 (33.0) 32 (31.4) 1.11 (0.61-2.01) 0.8567
  1. OR-odds ratio, CI-confidence interval, Pc, Yates corrected p value
  2. a - χ 2 = 6.3692, uncorrected p = 0.0434