Table 3 HLA-G genotype, allele and haplotype frequencies in patients and healthy siblings
Pooled | Male | Female | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients (99) n (%) | Healthysiblings (126) n (%) | OR (95% CI) | pc | Patients (52) n (%) | Healthy siblings (75) n (%) | OR (95% CI) | pc | Patients (47) n (%) | Healthy siblings (51) n (%) | OR (95% CI) | pc | |
14 bp Ins/Del | ||||||||||||
Genotypes | ||||||||||||
Ins/Ins | 16 (16.2) | 27 (21.4) | 0.71 (0.36-1.40) | 0.4084 | 9 (17.3) | 24 (32.0) | 0.44 (0.18-1.04) | 0.0987 | 7 (14.9) | 3 (5.9) | 2.86 (0.69-11.77) | 0.2418 |
Del/Del | 35 (35.3) | 36 (28.6) | 1.37 (0.78-2.40) | 0.3128 | 18 (34.6) | 19 (25.3) | 1.53 (0.71-3.32) | 0.3755 | 17 (36.2) | 17 (33.3) | 1.17 (0.51-2.68) | 0.8791 |
Ins/Del | 48 (48.5) | 63 (50.0) | 0.94 (0.55-1.59) | 0.9272 | 25 (48.1) | 32 (42.7) | 1.24 (0.61-2.53) | 0.6734 | 23 (48.9) | 31 (60.8) | 0.62 (0.28-1.38) | 0.3296 |
Alleles | ||||||||||||
Ins | 80 (40.4) | 117 (46.4) | 0.78 (0.54-1.14) | 0.2368 | 43 (41.3) | 80 (53.3) | 0.62 (0.37-1.02) | 0.0797 | 37 (39.4) | 37 (36.3) | 1.14 (0.64-2.03) | 0.7657 |
Del | 118 (59.6) | 135 (53.6) | 1.28 (0.88-1.86) | 0.2368 | 61 (58.7) | 70 (46.7) | 1.62 (0.98-2.70) | 0.0797 | 57 (60.6) | 65 (63.7) | 0.88 (0.49-1.56) | 0.7657 |
+3142 C/G | ||||||||||||
Genotypes | ||||||||||||
C/C | 12 (12.1) | 6 (4.8) | 2.76 (0.99-7.63) | 0.0763a | 7 (13.5) | 3 (4.0) | 3.68 (0.90-14.98) | 0.1121 | 5 (10.6) | 3 (5.9) | 1.94 (0.44-8.62) | 0.6041 |
G/G | 48 (48.5) | 66 (52.4) | 0.86 (0.50-1.45) | 0.6556 | 27 (51.9) | 44 (58.7) | 0.76 (0.37-1.55) | 0.5680 | 21 (44.7) | 22 (43.1) | 1.06 (0.48-2.37) | 0.9602 |
C/G | 39 (39.4) | 54 (42.8) | 0.87 (0.51-1.48) | 0.6985 | 18 (34.6) | 28 (37.3) | 0.87 (0.41-1.82) | 0.8556 | 21 (44.7) | 26 (51.0) | 0.81 (0.37-1.78) | 0.7431 |
Alleles | ||||||||||||
C | 63 (31.8) | 66 (26.2) | 1.31 (0.87-1.98) | 0.2280 | 32 (30.8) | 34 (22.7) | 1.52 (0.86-2.66) | 0.1927 | 31 (33.0) | 32 (31.4) | 1.08 (0.59-1.96) | 0.9302 |
G | 135 (68.2) | 186 (73.8) | 0.76 (0.50-1.15) | 0.2280 | 72 (69.2) | 116 (77.3) | 0.66 (0.37-1.16) | 0.1927 | 63 (67.0) | 70 (68.6) | 0.93 (0.51-1.69) | 0.9302 |
Haplotypes | ||||||||||||
Ins/G | 80 (40.4) | 117 (46.4) | 0.78 (0.54-1.40) | 0.2368 | 43 (41.3) | 80 (53.3) | 0.62 (0.37-1.02) | 0.0797 | 37 (39.4) | 37 (36.3) | 1.14 (0.64-2.03) | 0.7657 |
Del/G | 55 (27.8) | 69 (27.4) | 1.02 (0.67-1.55) | 0.9898 | 29 (27.9) | 36 (24.0) | 1.22 (0.69-2.16) | 0.5813 | 26 (27.6) | 33 (32.3) | 0.80 (0.43-1.48) | 0.5756 |
Del/C | 63 (31.8) | 66 (26.2) | 1.31 (0.87-1.98) | 0.2280 | 32 (30.8) | 34 (22.7) | 1.49 (0.85-2.62) | 0.2148 | 31 (33.0) | 32 (31.4) | 1.11 (0.61-2.01) | 0.8567 |