|
Pooled
|
Male
|
Female
|
---|
Patients (99) n (%)
|
Healthysiblings (126) n (%)
|
OR (95% CI)
|
pc
|
Patients (52) n (%)
|
Healthy siblings (75) n (%)
|
OR (95% CI)
|
pc
|
Patients (47) n (%)
|
Healthy siblings (51) n (%)
|
OR (95% CI)
|
pc
|
---|
14 bp Ins/Del
|
Genotypes
|
Ins/Ins
|
16 (16.2)
|
27 (21.4)
|
0.71 (0.36-1.40)
|
0.4084
|
9 (17.3)
|
24 (32.0)
|
0.44 (0.18-1.04)
|
0.0987
|
7 (14.9)
|
3 (5.9)
|
2.86 (0.69-11.77)
|
0.2418
|
Del/Del
|
35 (35.3)
|
36 (28.6)
|
1.37 (0.78-2.40)
|
0.3128
|
18 (34.6)
|
19 (25.3)
|
1.53 (0.71-3.32)
|
0.3755
|
17 (36.2)
|
17 (33.3)
|
1.17 (0.51-2.68)
|
0.8791
|
Ins/Del
|
48 (48.5)
|
63 (50.0)
|
0.94 (0.55-1.59)
|
0.9272
|
25 (48.1)
|
32 (42.7)
|
1.24 (0.61-2.53)
|
0.6734
|
23 (48.9)
|
31 (60.8)
|
0.62 (0.28-1.38)
|
0.3296
|
Alleles
|
Ins
|
80 (40.4)
|
117 (46.4)
|
0.78 (0.54-1.14)
|
0.2368
|
43 (41.3)
|
80 (53.3)
|
0.62 (0.37-1.02)
|
0.0797
|
37 (39.4)
|
37 (36.3)
|
1.14 (0.64-2.03)
|
0.7657
|
Del
|
118 (59.6)
|
135 (53.6)
|
1.28 (0.88-1.86)
|
0.2368
|
61 (58.7)
|
70 (46.7)
|
1.62 (0.98-2.70)
|
0.0797
|
57 (60.6)
|
65 (63.7)
|
0.88 (0.49-1.56)
|
0.7657
|
+3142 C/G
|
Genotypes
|
C/C
|
12 (12.1)
|
6 (4.8)
|
2.76 (0.99-7.63)
|
0.0763a
|
7 (13.5)
|
3 (4.0)
|
3.68 (0.90-14.98)
|
0.1121
|
5 (10.6)
|
3 (5.9)
|
1.94 (0.44-8.62)
|
0.6041
|
G/G
|
48 (48.5)
|
66 (52.4)
|
0.86 (0.50-1.45)
|
0.6556
|
27 (51.9)
|
44 (58.7)
|
0.76 (0.37-1.55)
|
0.5680
|
21 (44.7)
|
22 (43.1)
|
1.06 (0.48-2.37)
|
0.9602
|
C/G
|
39 (39.4)
|
54 (42.8)
|
0.87 (0.51-1.48)
|
0.6985
|
18 (34.6)
|
28 (37.3)
|
0.87 (0.41-1.82)
|
0.8556
|
21 (44.7)
|
26 (51.0)
|
0.81 (0.37-1.78)
|
0.7431
|
Alleles
|
C
|
63 (31.8)
|
66 (26.2)
|
1.31 (0.87-1.98)
|
0.2280
|
32 (30.8)
|
34 (22.7)
|
1.52 (0.86-2.66)
|
0.1927
|
31 (33.0)
|
32 (31.4)
|
1.08 (0.59-1.96)
|
0.9302
|
G
|
135 (68.2)
|
186 (73.8)
|
0.76 (0.50-1.15)
|
0.2280
|
72 (69.2)
|
116 (77.3)
|
0.66 (0.37-1.16)
|
0.1927
|
63 (67.0)
|
70 (68.6)
|
0.93 (0.51-1.69)
|
0.9302
|
Haplotypes
|
Ins/G
|
80 (40.4)
|
117 (46.4)
|
0.78 (0.54-1.40)
|
0.2368
|
43 (41.3)
|
80 (53.3)
|
0.62 (0.37-1.02)
|
0.0797
|
37 (39.4)
|
37 (36.3)
|
1.14 (0.64-2.03)
|
0.7657
|
Del/G
|
55 (27.8)
|
69 (27.4)
|
1.02 (0.67-1.55)
|
0.9898
|
29 (27.9)
|
36 (24.0)
|
1.22 (0.69-2.16)
|
0.5813
|
26 (27.6)
|
33 (32.3)
|
0.80 (0.43-1.48)
|
0.5756
|
Del/C
|
63 (31.8)
|
66 (26.2)
|
1.31 (0.87-1.98)
|
0.2280
|
32 (30.8)
|
34 (22.7)
|
1.49 (0.85-2.62)
|
0.2148
|
31 (33.0)
|
32 (31.4)
|
1.11 (0.61-2.01)
|
0.8567
|
- OR-odds ratio, CI-confidence interval, Pc, Yates corrected p value
- a - χ
2 = 6.3692, uncorrected p = 0.0434