A comparison of three treatment strategies in recent onset non-systemic Juvenile Idiopathic Arthritis: initial 3-months results of the BeSt for Kids-study

Table 2 Outcome after 6 weeks and 3 months in BeSt for Kids study

	Arm 1 Sequential monotherapy n = 32	Arm 2 Combo MTX + 6 wks prednisone n = 32	Arm 3 Combo MTX+ etanercept n = 30	p
Inactive disease (%)* 6wks 3 mths	0 (0) 8 (25)	4 (13) 3 (9)	1 (3) 5 (17)	0.25
aACR Pedi 30 (%) 6 wks 3 mths	15 (47) 16 (50)	18 (56) 17 (53)	17 (57) 22 (73)	0.68 0.13
aACR Pedi 50 (%) 6wks 3 mths	9 (28) 10 (31)	14 (44) 12 (38)	11 (37) 16 (53)	0.56 0.19
aACR Pedi 70 (%) 6wks 3 mths	3 (9) 8 (25)	8(25) 6 (19)	6(20) 14 (47)	0.25 0.04
JADAS-10 (median) 6wks 3 mths Δ JADAS-10 (median) 6wks 3 mths	13.9 9.0 3.2 6.9	9.6 11.5 6.6 5.7	12.4 8.2 5.0 10.2	0.12 0.25 0.012 0.22

*according to our definition of inactive disease modified to Wallace 2004 definition: no active synovitis, no fever, rash, serositis, splenomegaly or generalized lymphadenopathy attributable to JIA. No active uveitis, ESR ≤ 16 mm/h and physician’s VAS <10 mm

ISSN: 1546-0096