SNPs | Allele/Genotypes | RA | P a,OR [95%CI] | JIA | P a,OR [95%CI] | RA | P a,OR [95%CI] | JIA | P a,OR [95%CI] | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RF+ (freq.) | RF− (freq.) | RF+(freq.) | RF− (freq.) | Anti-CCP+(freq.) | Anti-CCP−(freq.) | Anti-CCP+(freq.) | Anti-CCP−(freq.) | ||||||
rs4986790 | G | 0.11 | 0.13 | Â | 0.15 | 0.14 | Â | 0.25 | 0.21 | Â | 0.13 | 0.11 | Â |
 | A | 0.89 | 0.87 | 0.74,0.94 [0.65–1.36] | 0.85 | 0.86 | 0.82,1.07 [0.59–1.97] | 0.75 | 0.79 | 0.55,1.19 [0.66–2.15] | 0.87 | 0.89 | 0.84,1.26 [0.97–1.93] |
 | GG | 0.0 | 0.0 | – | – | – | – | 0.0 | 0.0 | – | 0.0 | 0.0 | – |
 | GA | 0.33 | 0.29 | 0.51,1.17 [0.73–1.86] | 0.31 | 0.30 | 0.84,1.06 [0.57–1.99] | 0.34 | 0.32 | 0.75,0.88 [0.42–1.86] | 0.29 | 0.27 | 0.64,1.22 [0.79–1.88] |
 | AA | 0.67 | 0.71 | 0.92,0.98 [0.63–1.52] | 0.69 | 0.70 | 0.84,0.94 [0.50–1.76] | 0.66 | 0.68 | 0.84,0.93 [0.45–1.90] | 0.71 | 0.73 | 0.79,0.46 [0.22–0.97] |
rs41426344 | C | 0.17 | 0.08 | Â | 0.19 | 0.08 | Â | 0.15 | 0.06 | Â | 0.16 | 0.05 | Â |
 | G | 0.83 | 0.92 | <.0001,2.33 [1.65–3..01] | 0.82 | 0.92 | 0.02,2.91 [1.11–7.56] | 0.85 | 0.94 | 0.008,2.79 [1.28–6.11] | 0.84 | 0.95 | 0.02,2.78 [1.21–6.74] |
 | CC | 0.04 | 0.01 | 0.01,1.45 [0.48–4.26] | 0.04 | 0.015 | 0.001,3.23 [0.39–26.79] | 0.03 | 0.01 | –,2.34 [0.27–20.45] | 0.02 | 0.01 | –,2.45 [0.36–18.75] |
 | CG | 0.30 | 0.13 | <.0001,2.82 [1.90–4.19] | 0.30 | 0.13 | 0.009,2.76 [1.26–6.05] | 0.23 | 0.09 | 0.003,3.37 [1.48–9.43] | 0.22 | 0.10 | 0.002,2.94 [1.39–8.25] |
 | GG | 0.66 | 0.86 | <.0001,0.37 [0.25–0.53] | 0.65 | 0.85 | 0.002,0.32 [0.15–0.69] | 0.74 | 0.90 | <.0001,0.21 [0.09–0.48] | 0.76 | 0.89 | <.0001,0.34 [0.11–0.85] |