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Table 5 Rs4986790 and rs41426344 allele/genotype frequencies and autoantibody levels in patients with RA and JIA

From: TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population

SNPs

Allele/Genotypes

RA

P a,OR [95%CI]

JIA

P a,OR [95%CI]

RA

P a,OR [95%CI]

JIA

P a,OR [95%CI]

RF+ (freq.)

RF− (freq.)

RF+(freq.)

RF− (freq.)

Anti-CCP+(freq.)

Anti-CCP−(freq.)

Anti-CCP+(freq.)

Anti-CCP−(freq.)

rs4986790

G

0.11

0.13

 

0.15

0.14

 

0.25

0.21

 

0.13

0.11

 
 

A

0.89

0.87

0.74,0.94 [0.65–1.36]

0.85

0.86

0.82,1.07 [0.59–1.97]

0.75

0.79

0.55,1.19 [0.66–2.15]

0.87

0.89

0.84,1.26 [0.97–1.93]

 

GG

0.0

0.0

–

–

–

–

0.0

0.0

–

0.0

0.0

–

 

GA

0.33

0.29

0.51,1.17 [0.73–1.86]

0.31

0.30

0.84,1.06 [0.57–1.99]

0.34

0.32

0.75,0.88 [0.42–1.86]

0.29

0.27

0.64,1.22 [0.79–1.88]

 

AA

0.67

0.71

0.92,0.98 [0.63–1.52]

0.69

0.70

0.84,0.94 [0.50–1.76]

0.66

0.68

0.84,0.93 [0.45–1.90]

0.71

0.73

0.79,0.46 [0.22–0.97]

rs41426344

C

0.17

0.08

 

0.19

0.08

 

0.15

0.06

 

0.16

0.05

 
 

G

0.83

0.92

<.0001,2.33 [1.65–3..01]

0.82

0.92

0.02,2.91 [1.11–7.56]

0.85

0.94

0.008,2.79 [1.28–6.11]

0.84

0.95

0.02,2.78 [1.21–6.74]

 

CC

0.04

0.01

0.01,1.45 [0.48–4.26]

0.04

0.015

0.001,3.23 [0.39–26.79]

0.03

0.01

–,2.34 [0.27–20.45]

0.02

0.01

–,2.45 [0.36–18.75]

 

CG

0.30

0.13

<.0001,2.82 [1.90–4.19]

0.30

0.13

0.009,2.76 [1.26–6.05]

0.23

0.09

0.003,3.37 [1.48–9.43]

0.22

0.10

0.002,2.94 [1.39–8.25]

 

GG

0.66

0.86

<.0001,0.37 [0.25–0.53]

0.65

0.85

0.002,0.32 [0.15–0.69]

0.74

0.90

<.0001,0.21 [0.09–0.48]

0.76

0.89

<.0001,0.34 [0.11–0.85]

  1. Abbreviation: SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence intervals; −, not calculated, RF rheumatoid factor, anti-CCP anti-cyclic citrullinated peptide
  2. a P value were calculated using Fisher’s exact test