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Table 2 Allele distributions of TLR4 gene polymorphisms in RA, JIA and healthy controls

From: TLR4 rs41426344 increases susceptibility of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) in a central south Chinese Han population

   

RA

   

JIA

   

SNPs (MAF)

Region

Position

Case (freq.)

Control (freq.)

P

P a adj

OR [95%CI]b

Case (freq.)

Control (freq.)

P

P a adj

OR [95%CI]b

rs10759932(C)

5’UTR

27786349

0.32

0.29

0.37

–

1.10 [0.89–1.34]

0.26

0.26

0.86

–

1.03 [0.78–1.34]

rs4986790 (G)

Exon 3

27796507

0.02

0.006

0.005

0.03

3.43 [1.39–8.45]

0.02

0.008

0.06

–

2.65 [0.93–7.49]

rs4986791 (T)

Exon 3

27796807

0.05

0.04

0.03

0.18

1.75 [1.09–2.82]

0.07

0.05

0.12

–

1.46 [0.90–2.37]

rs41426344 (C)

3’UTR

27799138

0.21

0.13

<0.001

<0.001

2.24 [1.76–2.85]

0.25

0.14

<0.001

<0.001

2.05 [1.52–2.77]

rs11536889 (C)

3’UTR

27799336

0.22

0.19

0.07

–

1.24 [0.98–1.56]

0.23

0.19

0.19

–

1.21 [0.91–1.61]

rs7873784 (C)

3’UTR

27800141

0.15

0.12

0.03

0.18

1.35 [1.03–1.77]

0.13

0.14

0.68

–

0.93 [0.66–1.31]

  1. Abbreviation: SNP, single nucleotide polymorphism, MAF minor allele frequency, OR odds ratio, 95% CI 95% confidence intervals, not calculated, RA Rheumatoid arthritis, JIA juvenile idiopathic arthritis, Freq frequency; padj, padjusted
  2. aThe Bonferroni’s correction was carried out to adjust the p value
  3. bOR and 95% CI are calculated for the minor allele of each SNP
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Pediatric Rheumatology

ISSN: 1546-0096