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Table 4 Adverse events that led to treatment discontinuation in 99 patients

From: Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept

Adverse event N
Recurrent or new-onset uveitis 38
Neuropsychiatric disorders 21
 Behavioral disorders 7
 Headache 6
 Mood disorders/difficulty concentrating 4
 Tics/unintentional movements 2
 Papilledema 1
 Hypoglossal nerve paralysis 1
Gastrointestinal disorders 15
 Inflammatory bowel diseases 10
 Persistent hypertransaminasemia 1
 Abdominal pain 1
 Peritonitis anti-DNA positive 1
 Acute pancreatitis 1
 Nausea or vomiting 1
Infection 13
 Recurrent herpes labialis 2
 Recurrent upper airway infections 2
 Fatal streptococcal sepsis 1
 Tuberculosis 1
 Varicella complicated by porpora fulminans and fasciitis 1
 Osteomyielitis 1
 Cellulitis 1
 Herpetic neuritis 1
 Herpes zoster 1
 CMV hepatitis 1
 Recurrent bronchitis 1
Mucocutaneous disorders 10
 Urticaria 4
 Urticaria angioedema 2
 Cutaneous vasculitis 2
 Itch 1
 Anal Condylomatosis 1
Haematological disorders 5
 Leukopenia 3
 Autoimmune thrombocytopenia 1
 Hypocomplementemia 1
Injection site reactions 4
Pain at injection site 3
Malignancy 2
 Thyroid carcinoma 1
 Bladder carcinoma 1
Others 6
 Persistent cervical lymphadenopathy 2
 Autoimmune thyroiditis 1
 Menometrorrhagia 1
 Abortion 1
 Renal lithiasis 1