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Table 2 Therapeutic data and disease activity states at cross-sectional visit in patients still receiving etanercept (n = 422)a

From: Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept

 

No assessed

No (%) positive

Concomitant therapies

 Systemic corticosteroids

422

20 (4.7)

 Intra-articular corticosteroids

422

11 (2.6)

 Methotrexate

422

200 (47.4)

 Salazopyrin

422

3 (0.7)

 Azathioprine

422

1 (0.2)

Disease activity states – Formal definitions

 Wallace criteria for inactive disease

392

164 (41.8)

 Wallace criteria for inactive disease without

 acute phase reactants

420

214 (51)

 Magni-Manzoni criteria for low disease activity

420

267 (63.6)

Disease activity states – JADAS10

 Inactive disease

422

196 (46.4)

 Low disease activityb

422

270 (64)

 Moderate disease activity

422

103 (24.4)

 High disease activity

422

49 (11.6)

Disease activity states – cJADAS10

 Inactive disease

422

205 (48.6)

 Low disease activityb

422

246 (58.3)

 Moderate disease activity

422

117 (27.7)

 High disease activity

422

59 (14)

Patients with no active joints

422

289 (68.5)

Patients with no swollen joints

422

313 (74.2)

Patients with no tender joints

422

299 (70.9)

Patients with no restricted joints

422

253 (60)

Patients with physician’s VAS = 0

422

239 (56.6)

Patients with ESR < 20 mm/h

398

321 (80.7)

Patients with normal CRP

402

341 (84.8)

Patients with JADI Articular = 0

419

324 (77.3)

Patients with JADI Extraarticular = 0

419

364 (86.9)

  1. IQR interquartile range, JADAS Juvenile Arthritis Disease Activity Score, VAS visual analog scale, ESR erythrocyte sedimentation rate, CRP C-reactive protein, JADI Juvenile Arthritis Damage Index
  2. aData are number (percentage) unless otherwise indicated
  3. bIncludes patients with inactive disease