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Fig. 2 | Pediatric Rheumatology

Fig. 2

From: Safety and efficacy of pregabalin in adolescents with fibromyalgia: a randomized, double-blind, placebo-controlled trial and a 6-month open-label extension study

Fig. 2

Primary efficacy outcome and sensitivity analyses in the double-blind trial BOCF baseline observation carried forward, CI confidence interval, FAS full analysis set; LOCF last observation carried forward, mBOCF modified baseline observation carried forward (applying BOCF rule for subjects discontinued due to adverse events and LOCF rule for subjects discontinued due to any other reason); SE standard error. For the primary outcome the FAS was assessed, where missing data for week 15 mean pain score were imputed based on distribution of baseline pain scores if patients discontinued due to adverse events or abnormal laboratory test results or lack of efficacy; otherwise, if subjects discontinued due to other reasons, it was imputed based on distribution of post-baseline weekly mean pain scores using Markov chain Monte Carlo method. Mean (SD) pain score at baseline was 6.94 (1.23) with pregabalin and 6.95 (1.27) with placebo

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